KCNAB1 potassium voltage-gated channel subfamily A member regulatory beta subunit 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: KCNAB1provided by CGNC
Full Name: potassium voltage-gated channel subfamily A member regulatory beta subunit 1provided by CGNC
Primary source: CGNC:49446
See related: Ensembl:ENSGALG00010001520
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: KCNAB3; KVB1.1
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 17

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	9	NC_052540.1 (22596669..22633214, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	9	NC_052581.1 (22381914..22418481, complement)

Chromosome 9 - NC_052540.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We conclude that the highly specialized abundant expression of Kv1.1 and 3.1 channel subunits is not permanently regulated by synaptic activity and that changes in overall protein levels do not predict membrane pools.
Title: Activity-dependent regulation of the potassium channel subunits Kv1.1 and Kv3.1.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables aldo-keto reductase (NADPH) activity	IEA Inferred from Electronic Annotation more info	PubMed
enables potassium channel regulator activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info	PubMed
enables voltage-gated potassium channel activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in negative regulation of delayed rectifier potassium channel activity	IEA Inferred from Electronic Annotation more info	PubMed
involved_in potassium ion transport	IEA Inferred from Electronic Annotation more info	PubMed
involved_in transmembrane transport	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed
located_in extrinsic component of cytoplasmic side of plasma membrane	IEA Inferred from Electronic Annotation more info	PubMed
located_in juxtaparanode region of axon	IEA Inferred from Electronic Annotation more info	PubMed
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed
part_of voltage-gated potassium channel complex	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: voltage-gated potassium channel subunit beta-1

Names: K(+) channel subunit beta-1; kv-beta-1; potassium channel Shaker beta 1 subunit cKvbeta1.1; potassium voltage-gated channel subfamily A regulatory beta subunit 3; potassium voltage-gated channel, shaker-related subfamily, beta member 1; putative potassim channel beta-subunit

NP_990237.1

EC 1.1.1.-

XP_015147135.1

EC 1.1.1.-

XP_040561400.1

EC 1.1.1.-

XP_040561401.1

EC 1.1.1.-

XP_040561402.1

EC 1.1.1.-

XP_046754277.1

EC 1.1.1.-

XP_046779553.1

EC 1.1.1.-

XP_046779554.1

EC 1.1.1.-

XP_046779555.1

EC 1.1.1.-

XP_046779556.1

EC 1.1.1.-

XP_046779557.1

EC 1.1.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204906.1 → NP_990237.1 voltage-gated potassium channel subunit beta-1

See identical proteins and their annotated locations for NP_990237.1

Status: PROVISIONAL

Source sequence(s)

U87787

UniProtKB/Swiss-Prot

Q9PWR1

UniProtKB/TrEMBL

A0A8V0X2R6

Related

ENSGALP00010001964.1, ENSGALT00010003522.1

Conserved Domains (2) summary

cd06660
Location:73 → 388

Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

TIGR01293
Location:73 → 389

Kv_beta; voltage-dependent potassium channel beta subunit, animal

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052540.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

22596669..22633214 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040705467.2 → XP_040561401.1 voltage-gated potassium channel subunit beta-1 isoform X3

Conserved Domains (1) summary

cl00470
Location:87 → 371

AKR_SF; Aldo-keto reductase (AKR) superfamily
XM_015291649.3 → XP_015147135.1 voltage-gated potassium channel subunit beta-1 isoform X1

Conserved Domains (2) summary

cd06660
Location:89 → 404

Aldo_ket_red; Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial ...

TIGR01293
Location:89 → 405

Kv_beta; voltage-dependent potassium channel beta subunit, animal
XM_040705466.2 → XP_040561400.1 voltage-gated potassium channel subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A8V0X2R6, A0A8V0XBX0

Related

ENSGALP00010001973.1, ENSGALT00010003531.1

Conserved Domains (1) summary

cd19159
Location:76 → 398

AKR_KCAB1B_AKR6A3-like; voltage-gated potassium channel subunit beta-1 (KCAB1B) and similar proteins
XM_040705468.2 → XP_040561402.1 voltage-gated potassium channel subunit beta-1 isoform X4

UniProtKB/TrEMBL

A0A8V0X2R6

Conserved Domains (1) summary

cl00470
Location:71 → 355

AKR_SF; Aldo-keto reductase (AKR) superfamily
XM_046898321.1 → XP_046754277.1 voltage-gated potassium channel subunit beta-1 isoform X5

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052581.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

22381914..22418481 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046923599.1 → XP_046779555.1 voltage-gated potassium channel subunit beta-1 isoform X3
XM_046923597.1 → XP_046779553.1 voltage-gated potassium channel subunit beta-1 isoform X1
XM_046923598.1 → XP_046779554.1 voltage-gated potassium channel subunit beta-1 isoform X2

UniProtKB/TrEMBL

A0A8V0XBX0
XM_046923600.1 → XP_046779556.1 voltage-gated potassium channel subunit beta-1 isoform X4
XM_046923601.1 → XP_046779557.1 voltage-gated potassium channel subunit beta-1 isoform X5