VAX1 ventral anterior homeobox 1 [Gallus gallus (chicken)] - Gene

Summary

Symbol: VAX1provided by CGNC
Full Name: ventral anterior homeobox 1provided by CGNC
Primary source: CGNC:49384
See related: Ensembl:ENSGALG00010017907
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: cVAX
Orthologs: human mouse all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 6

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	6	NC_052537.1 (29865294..29868726, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	6	NC_052578.1 (29755730..29759172, complement)

Chromosome 6 - NC_052537.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Hedgehog-regulated localization of Vax2 controls eye development
Title: Hedgehog-regulated localization of Vax2 controls eye development.
Results show that in the chick retina the compartmentalized expression of retinoic acid metabolizing enzymes RALDH-1, RALDH-3 and CYP26A1 requires the spatially restricted expression of the transcription factors cVax/Vax2 and Tbx5
Title: Regulation of RALDH-1, RALDH-3 and CYP26A1 by transcription factors cVax/Vax2 and Tbx5 in the embryonic chick retina.
novel functions for cVax in intraretinal axon fasciculation and pathfinding as well as suggest a mechanism to explain how restricted cVax expression may influence map formation along the dorso-ventral and antero-posterior axes of the optic tectum.
Title: Retroviral misexpression of cVax disturbs retinal ganglion cell axon fasciculation and intraretinal pathfinding in vivo and guidance of nasal ganglion cell axons in vivo.
cVax is required for establishing dorsal-ventral patterning of the neural retina.
Title: Misexpression of the Emx-related homeobox genes cVax and mVax2 ventralizes the retina and perturbs the retinotectal map.
Pax6 together with cVax and Tbx5 mediates dorsoventral patterning of the eye
Title: Pax6 interacts with cVax and Tbx5 to establish the dorsoventral boundary of the developing eye.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

Vax1 (e-PCR), detects polymorphism
- UniSTS:527604

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in brain development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in central nervous system development	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neuron differentiation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: ventral anterior homeobox 1

Names: Vax

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204799.3 → NP_990130.3 ventral anterior homeobox 1

Status: VALIDATED

Source sequence(s)

JAENSK010000232

UniProtKB/Swiss-Prot

Q9PTR3, Q9PVN2

UniProtKB/TrEMBL

F1P5G0

Related

ENSGALP00010025727.1, ENSGALT00010043289.1

Conserved Domains (1) summary

smart00389
Location:99 → 155

HOX; Homeodomain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052537.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

29865294..29868726 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052578.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

29755730..29759172 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)