NEUROG2 neurogenin 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: NEUROG2provided by CGNC
Full Name: neurogenin 2provided by CGNC
Primary source: CGNC:49383
See related: Ensembl:ENSGALG00010005569
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: NGN2/ATH4A; neurogenin-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (56643129..56644456)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (56647242..56648568)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ngn2 together with NeuroM serves as readout to regulate GFRalpha1 expression, which occurs in multiple subtypes of spinal neurons.
Title: Neurogenin2 expression together with NeuroM regulates GDNF family neurotrophic factor receptor α1 (GFRα1) expression in the embryonic spinal cord.
NEUROG2 activation leads to a rapid decrease of a subset of cell cycle regulators acting at G(1) and S phases, including CCND1, CCNE1/2, and CCNA2 but not CCND2.
Title: NEUROG2 drives cell cycle exit of neuronal precursors by specifically repressing a subset of cyclins acting at the G1 and S phases of the cell cycle.
There is a functional relationship between specific MTG and bHLH proteins in developing chick spinal cord.
Title: Interaction of MTG family proteins with NEUROG2 and ASCL1 in the developing nervous system.
Data show that MTGR1 physically interacts with NEUROG2 and represses transcriptional activity of NEUROG2.
Title: Feedback regulation of NEUROG2 activity by MTGR1 is required for progression of neurogenesis.
Downregulation of Pax6 expression can be controlled by high levels of Ngn2.
Title: The on/off of Pax6 controls the tempo of neuronal differentiation in the developing spinal cord.
NGN2 binds to the atonal homolog 5 promoter in retina but not in optic tectum
Title: Highly specific interactions between bHLH transcription factors and chromatin during retina development.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein dimerization activity	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: neurogenin-2

Names: atonal-like protein 4a

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001396188.1 → NP_001383117.1 neurogenin-2

Status: VALIDATED

Source sequence(s)

AF109014, AF123884, JAENSK010000074

UniProtKB/TrEMBL

Q9PTR9, Q9YH82

Related

ENSGALP00010007905.1, ENSGALT00010013344.1

Conserved Domains (2) summary

PRK12678
Location:5 → 90

PRK12678; transcription termination factor Rho; Provisional

cl00081
Location:70 → 133

bHLH_SF; basic Helix Loop Helix (bHLH) domain superfamily

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

56643129..56644456

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GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052576.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

56647242..56648568

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GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_204796.1: Suppressed sequence

Description

NM_204796.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.