MRE11 MRE11 homolog, double strand break repair nuclease [Gallus gallus (chicken)] - Gene

Summary

Symbol: MRE11provided by CGNC
Full Name: MRE11 homolog, double strand break repair nucleaseprovided by CGNC
Primary source: CGNC:12932
See related: Ensembl:ENSGALG00010008516
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: MRE11A
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 20

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	1	NC_052532.1 (185504555..185524345)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	1	NC_052573.1 (185554499..185574285)

Chromosome 1 - NC_052532.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Both the genome instability and cell death of MRE11-null and MRE11-mutated H129N cells are significantly reversed by overexpression of Tdp2, an enzyme that eliminates covalent Top2 conjugates; thus, the essential role of Mre11 nuclease activity is likely to remove the DNA lesions.
Title: Mre11 Is Essential for the Removal of Lethal Topoisomerase 2 Covalent Cleavage Complexes.
although Mre11 is required for efficient HR-dependent repair of ionizing-radiation-induced DSBs, Mre11 is largely dispensable for DSB resection in both chicken DT40 and human TK6 B cell lines.
Title: The role of the Mre11-Rad50-Nbs1 complex in double-strand break repair-facts and myths.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 3'-5'-DNA exonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed
enables DNA endonuclease activity	IEA Inferred from Electronic Annotation more info	PubMed
enables manganese ion binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in double-strand break repair via nonhomologous end joining	IEA Inferred from Electronic Annotation more info	PubMed
involved_in meiotic DNA double-strand break formation	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitochondrial double-strand break repair via homologous recombination	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic G2 DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in mitotic intra-S DNA damage checkpoint signaling	IEA Inferred from Electronic Annotation more info	PubMed
involved_in telomere maintenance	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
part_of Mre11 complex	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: double-strand break repair protein MRE11

Names: MRE11 homolog A, double strand break repair nuclease; MRE11 meiotic recombination 11 homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001397886.1 → NP_001384815.1 double-strand break repair protein MRE11

Status: VALIDATED

Source sequence(s)

JAENSK010000027

UniProtKB/Swiss-Prot

Q9IAM7

UniProtKB/TrEMBL

A0A8V0Y300

Conserved Domains (1) summary

cl27188
Location:10 → 402

Mre11_DNA_bind; Mre11 DNA-binding presumed domain
NM_001397887.1 → NP_001384816.1 double-strand break repair protein MRE11

Status: VALIDATED

Source sequence(s)

JAENSK010000027

UniProtKB/Swiss-Prot

Q9IAM7

UniProtKB/TrEMBL

A0A8V0Y300

Conserved Domains (1) summary

cl27188
Location:10 → 402

Mre11_DNA_bind; Mre11 DNA-binding presumed domain
NM_204778.2 → NP_990109.2 double-strand break repair protein MRE11

Status: VALIDATED

Source sequence(s)

JAENSK010000027

UniProtKB/Swiss-Prot

Q9IAM7

UniProtKB/TrEMBL

A0A8V0Y300

Related

ENSGALP00010011821.1, ENSGALT00010020323.1

Conserved Domains (1) summary

cl27188
Location:10 → 402

Mre11_DNA_bind; Mre11 DNA-binding presumed domain