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PRKDC protein kinase, DNA-activated, catalytic polypeptide [ Gallus gallus (chicken) ]

Gene ID: 395376, updated on 10-Oct-2024

Summary

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Official Symbol
PRKDCprovided by CGNC
Official Full Name
protein kinase, DNA-activated, catalytic polypeptideprovided by CGNC
Primary source
CGNC:49288
See related
Ensembl:ENSGALG00010005415
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
dnapkcs; DNA-PKCS
Orthologs
human mouse all
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Genomic context

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See PRKDC in Genome Data Viewer
Location:
chromosome: 2
Exon count:
86
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 2 NC_052533.1 (107585589..107670586, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 2 NC_052574.1 (107650974..107735969, complement)

Chromosome 2 - NC_052533.1Genomic Context describing neighboring genes Neighboring gene KIAA0146 Neighboring gene uncharacterized LOC121109539 Neighboring gene uncharacterized LOC121109537 Neighboring gene CCAAT/enhancer binding protein delta Neighboring gene uncharacterized LOC124417695 Neighboring gene transfer RNA alanine (anticodon AGC) Neighboring gene minichromosome maintenance complex component 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Identification of four highly conserved regions in DNA-PKcs. Fujimori A, et al. Immunogenetics, 2000 Sep. PMID 11003390
  2. KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation. Abe T, et al. Cell Signal, 2008 Nov. PMID 18674614
  3. The promoter regions of the Myb-regulated Adora2B and Mcm4 genes co-localize with origins of DNA replication. Gundelach H, et al. BMC Mol Biol, 2007 Sep 6. PMID 17822556, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. KU70 and DNA-PKcs unexpectedly function together during the induction of apoptosis.
    Title: KU70/80, DNA-PKcs, and Artemis are essential for the rapid induction of apoptosis after massive DSB formation.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables DNA-dependent protein kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in double-strand break repair via nonhomologous end joining IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in immunoglobulin V(D)J recombination IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in intrinsic apoptotic signaling pathway in response to DNA damage IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere maintenance IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
DNA-dependent protein kinase catalytic subunit
Names
DNA-PK catalytic subunit
NP_989989.4
XP_046766262.1
XP_046766263.1
XP_046766264.1
XP_046773902.1
XP_046773913.1
XP_046773922.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204658.4 → NP_989989.4  DNA-dependent protein kinase catalytic subunit

    Status: VALIDATED

    Source sequence(s)
    JAENSK010000043
    UniProtKB/Swiss-Prot
    P79791, Q8QGX4, Q9DEI2
    UniProtKB/TrEMBL
    A0A8V0XNN3
    Related
    ENSGALP00010007459.1, ENSGALT00010012897.1
    Conserved Domains (2) summary
    COG5032
    Location:3505 → 4021
    TEL1; Phosphatidylinositol kinase or protein kinase, PI-3 family [Signal transduction mechanisms]
    cd05172
    Location:3725 → 4021
    PIKKc_DNA-PK; Catalytic domain of DNA-dependent protein kinase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052533.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    107585589..107670586 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917946.1 → XP_046773902.1  DNA-dependent protein kinase catalytic subunit isoform X1

  2. XM_046917957.1 → XP_046773913.1  DNA-dependent protein kinase catalytic subunit isoform X2

  3. XM_046917966.1 → XP_046773922.1  DNA-dependent protein kinase catalytic subunit isoform X3

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052574.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    107650974..107735969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046910306.1 → XP_046766262.1  DNA-dependent protein kinase catalytic subunit isoform X1

  2. XM_046910307.1 → XP_046766263.1  DNA-dependent protein kinase catalytic subunit isoform X2

  3. XM_046910308.1 → XP_046766264.1  DNA-dependent protein kinase catalytic subunit isoform X3

Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8QGX4.1 GenPept UniProtKB/Swiss-Prot:Q8QGX4

Gene LinkOut

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