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AXL AXL receptor tyrosine kinase [ Gallus gallus (chicken) ]

Gene ID: 395336, updated on 17-Aug-2024

Summary

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Symbol
AXLprovided by CGNC
Full Name
AXL receptor tyrosine kinaseprovided by CGNC
Primary source
CGNC:6554
See related
Ensembl:ENSGALG00010020153
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as
REK; TYRO3
Orthologs
human mouse all
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Genomic context

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Location:
chromosome: 5
Exon count:
19
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 5 NC_052536.1 (24445124..24484398)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 5 NC_052577.1 (24412597..24451867)

Chromosome 5 - NC_052536.1Genomic Context describing neighboring genes Neighboring gene RNA polymerase II associated protein 1 Neighboring gene transmembrane protein 151B-like Neighboring gene MAX dimerization protein MGA Neighboring gene microRNA 6685 Neighboring gene WD repeat domain 62

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Rek, a gene expressed in retina and brain, encodes a receptor tyrosine kinase of the Axl/Tyro3 family. Biscardi JS, et al. J Biol Chem, 1996 Nov 15. PMID 8910558
  2. Identification of receptor tyrosine kinases in the embryonic chicken lens. Potts JD, et al. Curr Eye Res, 1993 Aug. PMID 8222737
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables protein binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell migration IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in multicellular organism development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in phagocytosis IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in positive regulation of kinase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
part_of receptor complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
tyrosine-protein kinase receptor TYRO3
Names
Axl-related receptor tyrosine kinase
TYRO3 protein tyrosine kinase
protein-tyrosine kinase
retina-expressed kinase
NP_989958.2
XP_025006316.1
XP_025006317.1
XP_046773636.1
XP_046773637.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204627.3 → NP_989958.2  tyrosine-protein kinase receptor TYRO3 precursor

    Status: PROVISIONAL

    Source sequence(s)
    JAENSK010000214
    UniProtKB/Swiss-Prot
    Q98949
    Related
    ENSGALP00010028773.1, ENSGALT00010048696.1
    Conserved Domains (4) summary
    smart00408
    Location:44 → 109
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:213 → 305
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05074
    Location:495 → 778
    PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
    cd00096
    Location:48 → 52
    Ig; Ig strand B [structural motif]

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052536.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    24445124..24484398
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025150548.3 → XP_025006316.1  tyrosine-protein kinase receptor TYRO3 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZJL7
    Conserved Domains (5) summary
    cd05749
    Location:99 → 177
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    smart00408
    Location:14 → 79
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:183 → 275
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05074
    Location:465 → 748
    PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
    pfam00041
    Location:282 → 363
    fn3; Fibronectin type III domain

  2. XM_025150549.3 → XP_025006317.1  tyrosine-protein kinase receptor TYRO3 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZJL7
    Related
    ENSGALP00010028786.1, ENSGALT00010048710.1
    Conserved Domains (5) summary
    cd05749
    Location:99 → 177
    Ig2_Axl_Tyro3_like; Second immunoglobulin (Ig)-like domain of Axl/Tyro3 family receptor tyrosine kinases (RTKs)
    smart00408
    Location:14 → 79
    IGc2; Immunoglobulin C-2 Type
    cd00063
    Location:183 → 275
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd05074
    Location:465 → 748
    PTKc_Tyro3; Catalytic domain of the Protein Tyrosine Kinase, Tyro3
    pfam00041
    Location:282 → 363
    fn3; Fibronectin type III domain

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052577.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    24412597..24451867
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046917681.1 → XP_046773637.1  tyrosine-protein kinase receptor TYRO3 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZJL7

  2. XM_046917680.1 → XP_046773636.1  tyrosine-protein kinase receptor TYRO3 isoform X1

    UniProtKB/TrEMBL
    A0A8V0ZJL7
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q98949.1 GenPept UniProtKB/Swiss-Prot:Q98949

Gene LinkOut

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