EBF2 EBF transcription factor 2 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: EBF2provided by CGNC
Official Full Name: EBF transcription factor 2provided by CGNC
Primary source: CGNC:49200
See related: Ensembl:ENSGALG00010018726
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 22

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	22	NC_052553.1 (659387..788147)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	22	NC_052594.1 (672812..801575)

Chromosome 22 - NC_052553.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ectopic expression of retinoic acid (RA) led to up-regulation of cEbf2, 3 but did not change cEbf1 expression in somites. Expectedly, inhibition of RA by disulfiram resulted in downregulation of cEbf2, 3, but did not change cEbf1 expression in somites. The same RA gain and loss of function experiments did not change cEbf1-3 expression in pharyngeal arches.
Title: The effect of RA on the chick Ebf1-3 genes expression in somites and pharyngeal arches.
cEbf2 and cEbf3 genes are considered as lateral sclerotome markers which their expression is regulated by Bmp4 signals from the lateral plate mesoderm.
Title: Bmp4 regulates chick Ebf2 and Ebf3 gene expression in somite development.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info	PubMed
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: transcription factor COE2

Names: early B-cell factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001164536.2 → NP_001158008.1 transcription factor COE2

Status: PROVISIONAL

Source sequence(s)

JAENSK010000331

UniProtKB/TrEMBL

A0A8V0Z7A1, E1C814

Related

ENSGALP00010027038.1, ENSGALT00010045291.1

Conserved Domains (3) summary

cd01175
Location:253 → 337

IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...

pfam16422
Location:20 → 246

COE1_DBD; Transcription factor COE1 DNA-binding domain

pfam16423
Location:338 → 381

COE1_HLH; Transcription factor COE1 helix-loop-helix domain

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052553.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

659387..788147

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_040651469.1 → XP_040507403.1 transcription factor COE2 isoform X3

Conserved Domains (2) summary

cd01175
Location:105 → 189

IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...

cl17007
Location:1 → 98

COE_DBD; Colier/Olf/Early B-cell factor (EBF) DNA Binding Domain
XM_015297299.4 → XP_015152785.1 transcription factor COE2 isoform X1

UniProtKB/TrEMBL

A0A8V0Z7A1

Related

ENSGALP00010027035.1, ENSGALT00010045282.1

Conserved Domains (3) summary

cd01175
Location:253 → 337

IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...

pfam16422
Location:20 → 246

COE1_DBD; Transcription factor COE1 DNA-binding domain

pfam16423
Location:338 → 381

COE1_HLH; Transcription factor COE1 helix-loop-helix domain
XM_025142763.3 → XP_024998531.1 transcription factor COE2 isoform X2

UniProtKB/TrEMBL

A0A8V0Z1E5, A0A8V0Z7A1

Related

ENSGALP00010027033.1, ENSGALT00010045276.1

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052594.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

672812..801575

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046931580.1 → XP_046787536.1 transcription factor COE2 isoform X3
XM_046931578.1 → XP_046787534.1 transcription factor COE2 isoform X1
XM_046931579.1 → XP_046787535.1 transcription factor COE2 isoform X2

UniProtKB/TrEMBL

A0A8V0Z1E5