HS6ST2 heparan sulfate 6-O-sulfotransferase 2 [Gallus gallus (chicken)] - Gene

Summary

Symbol: HS6ST2provided by CGNC
Full Name: heparan sulfate 6-O-sulfotransferase 2provided by CGNC
Primary source: CGNC:49190
See related: Ensembl:ENSGALG00010017387
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: HS6ST-2
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 4

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	4	NC_052535.1 (3548748..3650092, complement)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	4	NC_052576.1 (3584020..3685485, complement)

Chromosome 4 - NC_052535.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The chick HS6ST-2 transcripts is preferentially localized in the anterior and posterior proximal regions of the limb buds, respectively.
Title: Functional analysis of chick heparan sulfate 6-O-sulfotransferases in limb bud development.
study showed that one heparan sulfate 2-O-sulfotransferase (HS2ST) and two isoforms of heparan sulfate 6-O-sulfotransferase (HS6ST-1 and -2) occurred in chick embryos and showed where the transcripts were distributed throughout the limb bud
Title: Distinctive expression patterns of heparan sulfate O-sulfotransferases and regional differences in heparan sulfate structure in chick limb buds.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables heparan sulfate 6-O-sulfotransferase activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: heparan-sulfate 6-O-sulfotransferase 2

Names: cHS6ST-2

NP_989821.1

EC 2.8.2.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204490.2 → NP_989821.1 heparan-sulfate 6-O-sulfotransferase 2

See identical proteins and their annotated locations for NP_989821.1

Status: VALIDATED

Source sequence(s)

JAENSK010000071

UniProtKB/Swiss-Prot

Q5ZJE1, Q76LW2

Related

ENSGALP00010024556.1, ENSGALT00010041958.1

Conserved Domains (1) summary

pfam03567
Location:80 → 345

Sulfotransfer_2; Sulfotransferase family

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052535.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

3548748..3650092 complement

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GenBank, FASTA, Sequence Viewer (Graphics)