CCL20 C-C motif chemokine ligand 20 [Gallus gallus (chicken)] - Gene

Summary

Official Symbol: CCL20provided by CGNC
Official Full Name: C-C motif chemokine ligand 20provided by CGNC
Primary source: CGNC:2171
See related: Ensembl:ENSGALG00010023872
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Also known as: MIP-3ALPHA
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 9

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	9	NC_052540.1 (9198467..9208358)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	9	NC_052581.1 (9007678..9009795)

Chromosome 9 - NC_052540.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Chicken CCL20 (chCCL20) and its specific receptor chCCR6, were characterized.
Title: Cloning, expression and functional characterization of chicken CCR6 and its ligand CCL20.
We hypothesize that Mip-3alpha and its CCR6 receptor promote pancreatic cancer cell invasion
Title: Co-localization of macrophage inflammatory protein-3alpha (Mip-3alpha) and its receptor, CCR6, promotes pancreatic cancer cell invasion.

Submit: New GeneRIF Correction

General gene information

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Markers

SCYA20sts1 (e-PCR), detects polymorphism
- UniSTS:280351

SCYA20sts2 (e-PCR), detects polymorphism
- UniSTS:280352

Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables CCR chemokine receptor binding	IEA Inferred from Electronic Annotation more info	PubMed
enables chemokine activity	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to tumor necrosis factor	IEA Inferred from Electronic Annotation more info	PubMed
involved_in cellular response to type II interferon	IEA Inferred from Electronic Annotation more info	PubMed
involved_in chemokine-mediated signaling pathway	IEA Inferred from Electronic Annotation more info	PubMed
involved_in immune response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info	PubMed
involved_in lymphocyte chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in monocyte chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in neutrophil chemotaxis	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of ERK1 and ERK2 cascade	IEA Inferred from Electronic Annotation more info	PubMed
involved_in positive regulation of GTPase activity	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: C-C motif chemokine 20

Names: chemokine (C-C motif) ligand 20; maacrophage inflammatory protein 3alpha

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204438.2 → NP_989769.1 C-C motif chemokine 20 precursor

See identical proteins and their annotated locations for NP_989769.1

Status: PROVISIONAL

Source sequence(s)

AB101005

UniProtKB/TrEMBL

Q8QG55

Related

ENSGALP00010035326.1, ENSGALT00010058167.1

Conserved Domains (1) summary

cd01119
Location:32 → 92

Chemokine_CC_DCCL; Chemokine_CC_DCCL: subgroup of the Chemokine_CC subgroup based on the presence of a DCCL motif involving the two N-terminal cysteine residues; includes a number of small inducible cytokines capable of reversibly inhibiting normal hematopoietic ...