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CDKN2A cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4) [ Gallus gallus (chicken) ]

Gene ID: 395077, updated on 17-Aug-2024

Summary

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Symbol
CDKN2Aprovided by CGNC
Full Name
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)provided by CGNC
Primary source
CGNC:49164
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Summary
This gene encodes a protein similar to one of two mammalian cyclin-dependent kinase inhibitor proteins which regulate the activity of cyclin-dependent protein kinases CDK4 and CDK6 which further cell cycle progression through G1. The protein encoded by this gene is similar to the mammalian ARF (alternate reading frame) protein which functions as a cyclin-dependent kinase inhibitor and participates in regulation of the p53 cell cycle pathway. The first exon of the mammalian ARF transcript is referred to as beta. The mammalian gene which encodes ARF can also produce a transcript encoding an unrelated protein known as p16INK4a which participates in the regulation of the retinoblastoma pathway. The p16INK4a transcript contains an alternate first exon referred to as alpha, however, this transcript contains the same two downstream exons found in the ARF transcript. Sequence related to the alpha exon has not been found in the chicken genome and a p16INK4a transcript has not been detected, however, there is a duplication of exon two which suggests that the function of p16INK4a is provided by a protein from a different gene located nearby on chromosome Z. Although the protein encoded by this gene is smaller than the mammalian ARF protein, it has been shown to function in p53 regulation. [provided by RefSeq, Dec 2008]
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Genomic context

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See CDKN2A in Genome Data Viewer
Location:
chromosome: Z
Exon count:
2
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) Z NC_052572.1 (83329906..83339835, complement)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) Z NC_059536.1 (83329906..83339835, complement)

Chromosome Z - NC_052572.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107052435 Neighboring gene uncharacterized LOC112530597 Neighboring gene methylthioadenosine phosphorylase Neighboring gene cyclin dependent kinase inhibitor 2B Neighboring gene uncharacterized LOC107052436

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A. Schwochow Thalmann D, et al. PLoS Genet, 2017 Apr. PMID 28388616, Free PMC Article
  2. Absence of p16INK4a and truncation of ARF tumor suppressors in chickens. Kim SH, et al. Proc Natl Acad Sci U S A, 2003 Jan 7. PMID 12506196, Free PMC Article
  3. Binding to nucleophosmin determines the localization of human and chicken ARF but not its impact on p53. Moulin S, et al. Oncogene, 2008 Apr 10. PMID 17968318

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Our results show that CDKN2A is a major locus driving the differentiation of avian melanocytes in a temporal and spatial manner.
    Title: The evolution of Sex-linked barring alleles in chickens involves both regulatory and coding changes in CDKN2A.
  2. irrespective of the source or composition of the ARF fusion proteins, versions that accumulate in the nucleolus share the ability to bind to nucleophosmin [ARF]
    Title: Binding to nucleophosmin determines the localization of human and chicken ARF but not its impact on p53.
Submit: New GeneRIF Correction

Pathways from PubChem

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General protein information

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Preferred Names
ARF tumor suppressor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_204434.1 → NP_989765.1  ARF tumor suppressor

    See identical proteins and their annotated locations for NP_989765.1

    Status: REVIEWED

    Source sequence(s)
    AY138245
    UniProtKB/TrEMBL
    Q7ZTG3, Q7ZTG4

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052572.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    83329906..83339835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_059536.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    83329906..83339835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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