atp1a1 ATPase Na+/K+ transporting subunit alpha 1 [Xenopus tropicalis (tropical clawed frog)] - Gene

Summary

Official Symbol: atp1a1provided by Xenbase
Official Full Name: ATPase Na+/K+ transporting subunit alpha 1provided by Xenbase
Primary source: Xenbase:XB-GENE-484831
See related: Ensembl:ENSXETG00000020366 AllianceGenome:Xenbase:XB-GENE-484831
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus tropicalis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as: K-ATPase; atp1a1-a; atp1a1-b; atp1a1a.4; Na+K+ATPase
Summary: Predicted to enable P-type sodium:potassium-exchanging transporter activity. Predicted to be involved in intracellular monoatomic cation homeostasis and monoatomic cation transmembrane transport. Predicted to act upstream of or within potassium ion transport and sodium ion transport. Located in photoreceptor inner segment membrane. Is expressed in urinary system and vestibuloauditory system. Human ortholog(s) of this gene implicated in Charcot-Marie-Tooth disease type 2DD. Orthologous to human ATP1A1 (ATPase Na+/K+ transporting subunit alpha 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 2

Exon count:: 23

Annotation release	Status	Assembly	Chr	Location
104	current	UCB_Xtro_10.0 (GCF_000004195.4)	2	NC_030678.2 (1059164..1074508, complement)
103	previous assembly	Xenopus_tropicalis_v9.1 (GCF_000004195.3)	Unplaced Scaffold	NW_016683845.1 (37794..45903)

Chromosome 2 - NC_030678.2 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables P-type potassium transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables P-type sodium:potassium-exchanging transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in intracellular potassium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular sodium ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in potassium ion import across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within potassium ion transport	IEA Inferred from Electronic Annotation more info
involved_in proton transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in sodium ion export across plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within sodium ion transport	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in photoreceptor inner segment membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in sarcolemma	IBA Inferred from Biological aspect of Ancestor more info
located_in sarcolemma	IEA Inferred from Electronic Annotation more info
part_of sodium:potassium-exchanging ATPase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: sodium/potassium-transporting ATPase subunit alpha-1

Names: ATPase, Na+/K+ transporting, alpha 1 polypeptide; Na+/K+ ATPase; Na+K+ ATPase; sodium pump 1

NP_989407.1

EC 7.2.2.13

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204076.1 → NP_989407.1 sodium/potassium-transporting ATPase subunit alpha-1

See identical proteins and their annotated locations for NP_989407.1

Status: PROVISIONAL

Source sequence(s)

BC064884

UniProtKB/TrEMBL

A0A6I8SZW7, F6SMA8, Q6P1S7

Related

ENSXETP00000101199.2, ENSXETT00000067856.2

Conserved Domains (1) summary

TIGR01106
Location:32 → 1023

ATPase-IIC_X-K; sodium or proton efflux -- potassium uptake antiporter, P-type ATPase, alpha subunit