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Poc1 Proteome of centrioles 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39502, updated on 18-Sep-2024

Summary

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Official Symbol
Poc1provided by FlyBase
Official Full Name
Proteome of centrioles 1provided by FlyBase
Primary source
FLYBASE:FBgn0036354
Locus tag
Dmel_CG10191
See related
AllianceGenome:FB:FBgn0036354
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG10191; Dmel\CG10191; Pix; poc1; POC1
Summary
Involved in centrosome cycle. Predicted to be active in centriole and ciliary basal body. Is expressed in several structures, including embryonic brain; embryonic/larval nervous system; endoderm anlage; extended germ band embryo; and germ layer. Human ortholog(s) of this gene implicated in cone-rod dystrophy 20. Orthologous to human POC1A (POC1 centriolar protein A) and POC1B (POC1 centriolar protein B). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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See Poc1 in Genome Data Viewer
Location:
70A8-70A8; 3-40 cM
Exon count:
2
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (13388299..13390006, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (13381399..13383106, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene senseless Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pix proteins and the evolution of centrioles. Woodland HR, et al. PLoS One, 2008. PMID 19020665, Free PMC Article
  2. Poc1B and Sas-6 Function Together during the Atypical Centriole Formation in Drosophila melanogaster. Jo KH, et al. Cells, 2019 Aug 5. PMID 31387336, Free PMC Article
  3. Centriole Remodeling during Spermiogenesis in Drosophila. Khire A, et al. Curr Biol, 2016 Dec 5. PMID 28094036, Free PMC Article
  4. A proximal centriole-like structure is present in Drosophila spermatids and can serve as a model to study centriole duplication. Blachon S, et al. Genetics, 2009 May. PMID 19293139, Free PMC Article
  5. Functional Analysis of Hydrolethalus Syndrome Protein HYLS1 in Ciliogenesis and Spermatogenesis in Drosophila. Hou Y, et al. Front Cell Dev Biol, 2020. PMID 32509774, Free PMC Article

See all (34) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Process Evidence Code Pubs
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in ciliary basal body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
proteome of centrioles 1
Names
CG10191-PA
CG10191-PB
Poc1-PA
Poc1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    13388299..13390006 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001274870.1 → NP_001261799.1  proteome of centrioles 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261799.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    M9PCD6
    Conserved Domains (3) summary
    COG2319
    Location:14 → 388
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:10 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:22 → 58
    7WD40; WD40 repeat [structural motif]

  2. NM_140383.2 → NP_648640.1  proteome of centrioles 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VU65
    Related
    FBpp0075597
    Conserved Domains (3) summary
    COG2319
    Location:14 → 298
    WD40; WD40 repeat [General function prediction only]
    cd00200
    Location:10 → 298
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    sd00039
    Location:22 → 58
    7WD40; WD40 repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9PCD6 M9PCD6
Q9VU65.1 Q9VU65

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