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ebf2 EBF transcription factor 2 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 394808, updated on 4-Nov-2024

Summary

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Official Symbol
ebf2provided by Xenbase
Official Full Name
EBF transcription factor 2provided by Xenbase
Primary source
Xenbase:XB-GENE-971136
See related
Ensembl:ENSXETG00000010153 AllianceGenome:Xenbase:XB-GENE-971136
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
oe3; coe2; EBF-2; Mmot1; Xebf2; xcoe2; ebf2-a; ebf2-b
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within cell differentiation; nervous system development; and regulation of DNA-templated transcription. Predicted to be located in nucleus. Orthologous to human EBF2 (EBF transcription factor 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ebf2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
17
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (127859203..127910781, complement)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (106357829..106409424)

Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene potassium channel tetramerization domain containing 9 Neighboring gene cell division cycle associated 2 Neighboring gene protein phosphatase 2 regulatory subunit B, alpha Neighboring gene BCL2/adenovirus E1B 19kDa interacting protein 3-like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system development IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
transcription factor coe2
Names
early B cell factor 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203869.1 → NP_989200.1  transcription factor coe2

    See identical proteins and their annotated locations for NP_989200.1

    Status: PROVISIONAL

    Source sequence(s)
    BC063360
    UniProtKB/Swiss-Prot
    Q6P4K7
    UniProtKB/TrEMBL
    A0A6I8RH78
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    127859203..127910781 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012958769.3 → XP_012814223.1  transcription factor coe2 isoform X2

    UniProtKB/TrEMBL
    A0A6I8R0P0, A0A6I8RH78
    Related
    ENSXETP00000075500.1, ENSXETT00000097004.2
    Conserved Domains (3) summary
    cd01175
    Location:262 → 346
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:347 → 390
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  2. XM_012958768.3 → XP_012814222.1  transcription factor coe2 isoform X1

    UniProtKB/TrEMBL
    A0A6I8RH78, G1K3E3
    Related
    ENSXETP00000022402.3, ENSXETT00000022402.5
    Conserved Domains (3) summary
    cd01175
    Location:262 → 346
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:347 → 390
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain

  3. XM_012958770.3 → XP_012814224.1  transcription factor coe2 isoform X3

    UniProtKB/TrEMBL
    A0A6I8RH78, A0A8J0SGV8
    Related
    ENSXETP00000080974.2, ENSXETT00000099413.2
    Conserved Domains (3) summary
    cd01175
    Location:254 → 338
    IPT_COE; IPT domain of the COE family (Col/Olf-1/EBF) of non-basic, helix-loop-helix (HLH)-containing transcription factors. COE family proteins are all transcription factors and play an important role in variety of developmental processes. Mouse EBF is involved ...
    pfam16422
    Location:21 → 247
    COE1_DBD; Transcription factor COE1 DNA-binding domain
    pfam16423
    Location:339 → 382
    COE1_HLH; Transcription factor COE1 helix-loop-helix domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P4K7.1 GenPept UniProtKB/Swiss-Prot:Q6P4K7

Gene LinkOut

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