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itgb1 integrin subunit beta 1 [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 394767, updated on 4-Nov-2024

Summary

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Official Symbol
itgb1provided by Xenbase
Official Full Name
integrin subunit beta 1provided by Xenbase
Primary source
Xenbase:XB-GENE-946725
See related
Ensembl:ENSXETG00000026716 AllianceGenome:Xenbase:XB-GENE-946725
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
cd29; fnrb; mdf2; vlab; gpiia; msk12; itgb1-a; itgb1-b; vla-beta
Summary
Acts upstream of or within gastrulation with mouth forming second. Predicted to be located in several cellular components, including lamellipodium; melanosome; and ruffle membrane. Is expressed in mesoderm; musculoskeletal system; nervous system; pharyngeal arch; and visual system. Orthologous to human ITGB1 (integrin subunit beta 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See itgb1 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
17
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 6 NC_030682.2 (22871901..22896284)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 6 NC_030682.1 (14625451..14650164)

Chromosome 6 - NC_030682.2Genomic Context describing neighboring genes Neighboring gene par-3 family cell polarity regulator Neighboring gene neuropilin 1 Neighboring gene uncharacterized LOC108647848 Neighboring gene enhancer of polycomb homolog 1 Neighboring gene kinesin family member 5B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vimentin filament controls integrin α5β1-mediated cell adhesion by binding to integrin through its Ser38 residue. Kim J, et al. FEBS Lett, 2016 Oct. PMID 27658040
  2. Defining synphenotype groups in Xenopus tropicalis by use of antisense morpholino oligonucleotides. Rana AA, et al. PLoS Genet, 2006 Nov 17. PMID 17112317, Free PMC Article
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results found that direct interaction of vimentin with integrin beta1 can enhance binding of integrin alpha5beta1 to its ligand, fibronectin.
    Title: Vimentin filament controls integrin α5β1-mediated cell adhesion by binding to integrin through its Ser38 residue.
Submit: New GeneRIF Correction

General gene information

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Homology

Clone Names

  • MGC76178

Gene Ontology Provided by Xenbase

Process Evidence Code Pubs
acts_upstream_of_or_within cell adhesion IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within gastrulation with mouth forming second IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle organ development IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
located_in cell projection IEA
Inferred from Electronic Annotation
more info
  
located_in lamellipodium IEA
Inferred from Electronic Annotation
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in ruffle membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
integrin beta-1
Names
Beta 1 integrin
integrin beta 1 (fibronectin receptor beta)
integrin, beta 1 (fibronectin receptor, beta polypeptide, antigen CD29 includes MDF2, MSK12)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203829.1 → NP_989160.1  integrin beta-1 precursor

    See identical proteins and their annotated locations for NP_989160.1

    Status: PROVISIONAL

    Source sequence(s)
    BC063214
    UniProtKB/TrEMBL
    A0A6I8SUK5, Q6P4X1
    Related
    ENSXETP00000048743.5, ENSXETT00000048743.5
    Conserved Domains (5) summary
    smart00187
    Location:35 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07974
    Location:599 → 630
    EGF_2; EGF-like domain
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757 → 795
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:466 → 495
    I-EGF_1; Integrin beta epidermal growth factor like domain 1

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030682.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    22871901..22896284
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012964425.2 → XP_012819879.1  integrin beta-1 isoform X1

    UniProtKB/TrEMBL
    A0A6I8QX02, A0A6I8S833, A0A6I8SUK5
    Related
    ENSXETP00000078034.2, ENSXETT00000086410.2
    Conserved Domains (5) summary
    smart00187
    Location:35 → 464
    INB; Integrin beta subunits (N-terminal portion of extracellular region)
    pfam07974
    Location:599 → 630
    EGF_2; EGF-like domain
    pfam07965
    Location:640 → 727
    Integrin_B_tail; Integrin beta tail domain
    pfam08725
    Location:757 → 796
    Integrin_b_cyt; Integrin beta cytoplasmic domain
    pfam18372
    Location:466 → 495
    I-EGF_1; Integrin beta epidermal growth factor like domain 1
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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