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npm1 nucleophosmin (nucleolar phosphoprotein B23, numatrin) [ Xenopus tropicalis (tropical clawed frog) ]

Gene ID: 394478, updated on 4-Nov-2024

Summary

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Official Symbol
npm1provided by Xenbase
Official Full Name
nucleophosmin (nucleolar phosphoprotein B23, numatrin)provided by Xenbase
Primary source
Xenbase:XB-GENE-1019571
See related
Ensembl:ENSXETG00000008403 AllianceGenome:Xenbase:XB-GENE-1019571
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus tropicalis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana
Also known as
b23; npm; numatrin
Summary
Predicted to enable RNA binding activity. Predicted to be located in cytoplasm; nucleolus; and nucleoplasm. Is expressed in dermal system. Human ortholog(s) of this gene implicated in acute myeloid leukemia. Orthologous to human NPM1 (nucleophosmin 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See npm1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Annotation release Status Assembly Chr Location
104 current UCB_Xtro_10.0 (GCF_000004195.4) 3 NC_030679.2 (20063551..20073882)
103 previous assembly Xenopus_tropicalis_v9.1 (GCF_000004195.3) 3 NC_030679.1 (9664013..9674014)

Chromosome 3 - NC_030679.2Genomic Context describing neighboring genes Neighboring gene catenin alpha 1 Neighboring gene heat shock protein family A (Hsp70) member 9 Neighboring gene solute carrier family 23 member 1 Neighboring gene fms related tyrosine kinase 4

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC75688

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables nucleic acid binding IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
nucleophosmin
Names
nucleophosmin 1
nucleoplasmin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_203552.1 → NP_988883.1  nucleophosmin

    See identical proteins and their annotated locations for NP_988883.1

    Status: PROVISIONAL

    Source sequence(s)
    BC059736
    UniProtKB/TrEMBL
    A0A803KIF9, F7DHY5, Q6PBF8
    Related
    ENSXETP00000018419.3, ENSXETT00000018419.4
    Conserved Domains (2) summary
    pfam03066
    Location:19 → 118
    Nucleoplasmin; Nucleoplasmin/nucleophosmin domain
    pfam16276
    Location:251 → 295
    NPM1-C; Nucleophosmin C-terminal domain

RefSeqs of Annotated Genomes: Xenopus tropicalis Annotation Release 104 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference UCB_Xtro_10.0 Primary Assembly

Genomic

  1. NC_030679.2 Reference UCB_Xtro_10.0 Primary Assembly

    Range
    20063551..20073882
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_012958741.2 → XP_012814195.1  nucleophosmin isoform X1

    UniProtKB/TrEMBL
    A0A6I8QQT5, A0A803KIF9
    Related
    ENSXETP00000071986.1, ENSXETT00000079739.2
    Conserved Domains (2) summary
    pfam03066
    Location:19 → 118
    Nucleoplasmin; Nucleoplasmin/nucleophosmin domain
    pfam16276
    Location:221 → 265
    NPM1-C; Nucleophosmin C-terminal domain
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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