pole.L polymerase (DNA directed), epsilon, catalytic subunit L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pole.L
Official Full Name: polymerase (DNA directed), epsilon, catalytic subunit L homeolog
Primary source: Xenbase:XB-GENE-1011592
Locus tag: XELAEV_18007393mg
See related: EnsemblRapid:ENSXLAG00005017012 AllianceGenome:Xenbase:XB-GENE-1011592
Gene type: protein coding
RefSeq status: MODEL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: pole; pole1; pole-A
Summary: Predicted to enable several functions, including 4 iron, 4 sulfur cluster binding activity; catalytic activity, acting on DNA; and zinc ion binding activity. Predicted to act upstream of or within DNA metabolic process and mitotic cell cycle. Predicted to be located in nuclear lumen. Predicted to be part of epsilon DNA polymerase complex. Human ortholog(s) of this gene implicated in colorectal cancer (multiple); endometrial cancer (multiple); lung cancer (multiple); and mismatch repair cancer syndrome. Orthologous to human POLE (DNA polymerase epsilon, catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	1L	NC_054371.1 (156116960..156168548, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	1L	NC_030724.1 (143146584..143198336, complement)

Chromosome 1L - NC_054371.1 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Function	Evidence Code	Pubs
enables 4 iron, 4 sulfur cluster binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-directed DNA polymerase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables single-stranded DNA 3'-5' DNA exonuclease activity	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA metabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication proofreading	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within base-excision repair, gap-filling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leading strand elongation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mitotic cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleotide-excision repair, DNA gap filling	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of epsilon DNA polymerase complex	IEA Inferred from Electronic Annotation more info
located_in nuclear lumen	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

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The following sections contain reference sequences that belong to a specific genome build. Explain