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ptprc.L protein tyrosine phosphatase, receptor type C L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 394345, updated on 4-Nov-2024

Summary

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Official Symbol
ptprc.L
Official Full Name
protein tyrosine phosphatase, receptor type C L homeolog
Primary source
Xenbase:XB-GENE-981260
Locus tag
XELAEV_18023456mg
See related
EnsemblRapid:ENSXLAG00005012827 AllianceGenome:Xenbase:XB-GENE-981260
Gene type
protein coding
RefSeq status
MODEL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
CD45; ptprc; ptprc-a
Summary
Predicted to enable protein tyrosine phosphatase activity. Predicted to act upstream of or within protein dephosphorylation; regulation of protein phosphorylation; and synaptic membrane adhesion. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in multiple sclerosis; primary immunodeficiency disease; and severe combined immunodeficiency. Orthologous to human PTPRC (protein tyrosine phosphatase receptor type C). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ptprc.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
34
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (108050387..108134415)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (102790975..102875249)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene serine/threonine-protein kinase Nek7-like Neighboring gene ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G3 L homeolog Neighboring gene uncharacterized LOC121403079 Neighboring gene uncharacterized LOC121403080

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bipotential primitive-definitive hematopoietic progenitors in the vertebrate embryo. Turpen JB, et al. Immunity, 1997 Sep. PMID 9324353

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within positive regulation of peptidyl-tyrosine phosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein dephosphorylation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within synaptic membrane adhesion IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
receptor-type tyrosine-protein phosphatase C
Names
protein tyrosine phosphatase, receptor type, C

NCBI Reference Sequences (RefSeq)

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RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    108050387..108134415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_041590597.1 → XP_041446531.1  receptor-type tyrosine-protein phosphatase C isoform X1

    UniProtKB/TrEMBL
    A0A8J1MYI0, A0A974HPP3
    Related
    ENSXLAP00005037744.1, ENSXLAT00005038655.1
    Conserved Domains (3) summary
    cd00063
    Location:402 → 489
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:710 → 909
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:1019 → 1224
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  2. XM_041590598.1 → XP_041446532.1  receptor-type tyrosine-protein phosphatase C isoform X2

    UniProtKB/TrEMBL
    A0A8J1MXL6, A0A974HPP3
    Conserved Domains (3) summary
    cd00063
    Location:402 → 485
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:706 → 905
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:1015 → 1220
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  3. XM_041590599.1 → XP_041446533.1  receptor-type tyrosine-protein phosphatase C isoform X3

    UniProtKB/TrEMBL
    A0A8J1MZ26, A0A974HPP3
    Related
    ENSXLAP00005037753.1, ENSXLAT00005038664.1
    Conserved Domains (3) summary
    cd00063
    Location:355 → 442
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:663 → 862
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:972 → 1177
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  4. XM_041590600.1 → XP_041446534.1  receptor-type tyrosine-protein phosphatase C isoform X4

    UniProtKB/TrEMBL
    A0A8J1MXD2, A0A974HPP3
    Related
    ENSXLAP00005037761.1, ENSXLAT00005038672.1
    Conserved Domains (3) summary
    cd00063
    Location:308 → 395
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:616 → 815
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:925 → 1130
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  5. XM_018258666.2 → XP_018114155.1  receptor-type tyrosine-protein phosphatase C isoform X5

    UniProtKB/TrEMBL
    A0A8J0V1V6, A0A974HPP3

  6. XM_041590601.1 → XP_041446535.1  receptor-type tyrosine-protein phosphatase C isoform X6

    UniProtKB/TrEMBL
    A0A8J1MZU9
    Conserved Domains (3) summary
    cd00063
    Location:240 → 327
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:548 → 747
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:857 → 1062
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2

  7. XM_041590602.1 → XP_041446536.1  receptor-type tyrosine-protein phosphatase C isoform X7

    UniProtKB/TrEMBL
    A0A8J1MYI5
    Conserved Domains (3) summary
    cd00063
    Location:209 → 296
    FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    cd14557
    Location:517 → 716
    R-PTPc-C-1; catalytic domain of receptor-type tyrosine-protein phosphatase C, repeat 1
    cd14558
    Location:826 → 1031
    R-PTP-C-2; PTP-like domain of receptor-type tyrosine-protein phosphatase C, repeat 2
Nucleotide Protein Strain
Heading Accession and Version

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