tfap2a.L transcription factor AP-2 alpha L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: tfap2a.L
Official Full Name: transcription factor AP-2 alpha L homeolog
Primary source: Xenbase:XB-GENE-6254445
Locus tag: XELAEV_18031635mg
See related: EnsemblRapid:ENSXLAG00005018326 AllianceGenome:Xenbase:XB-GENE-6254445
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: ap2; AP-2; AP2a; xap2; XAP-2; tfap2a; AP2alpha; tfap2a-a; tfap2a-b; tfap2alpha
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within regulation of cell population proliferation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in anatomical system; ectoderm; mesenchyme; and pharyngeal arch. Human ortholog(s) of this gene implicated in branchiooculofacial syndrome. Orthologous to human TFAP2A (transcription factor AP-2 alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 6L

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	6L	NC_054381.1 (95496141..95515463, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	6L	NC_030734.1 (88745664..88764442, complement)

Chromosome 6L - NC_054381.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Here, the authors show that adam13 interacts with the arid3a/dril1/Bright transcription factor. This interaction promotes a proteolytic cleavage of arid3a and its translocation to the nucleus where it regulates another transcription factor: tfap2alpha. Tfap2alpha in turn activates multiple genes including the protocadherin pcdh8l (PCNS).
Title: Dual control of pcdh8l/PCNS expression and function in Xenopus laevis neural crest cells by adam13/33 via the transcription factors tfap2α and arid3a.
AP2a initiates neural border patterning and is sufficient to elicit a neural border-like pattern in neuralized ectoderm.
Title: Reiterative AP2a activity controls sequential steps in the neural crest gene regulatory network.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: to transcription factor AP-2 alpha L homeolog; transcription factor AP-2 alpha L homeolog

Names: transcription factor AP-2 alpha (activating enhancer binding protein 2 alpha) L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087569.1 → NP_001081038.1 transcription factor AP-2 alpha L homeolog

See identical proteins and their annotated locations for NP_001081038.1

Status: PROVISIONAL

Source sequence(s)

M59455

UniProtKB/TrEMBL

A0A974CJT6, Q91867

Related

ENSXLAP00005054240.1, ENSXLAT00005055414.1

Conserved Domains (1) summary

pfam03299
Location:198 → 398

TF_AP-2; Transcription factor AP-2

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054381.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

95496141..95515463 complement

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GenBank, FASTA, Sequence Viewer (Graphics)