pcna.S proliferating cell nuclear antigen S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: pcna.S
Official Full Name: proliferating cell nuclear antigen S homeolog
Primary source: Xenbase:XB-GENE-972527
Locus tag: XELAEV_18020338mg
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: pcna; pcna-A
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Genomic context

Location:: chromosome: 3S

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3S	NC_054376.1 (30617838..30623298, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3S	NC_030729.1 (29475677..29481139, complement)

Chromosome 3S - NC_054376.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

residue in PCNA that is essential to support destruction of all CRL4(Cdt2) substrates
Title: Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.
CRL4Cdt2 ubiquitin ligase directly associates with pcna through its C-terminal domain.
Title: The CRL4Cdt2 ubiquitin ligase mediates the proteolysis of cyclin-dependent kinase inhibitor Xic1 through a direct association with PCNA.
Immunodepletion of Swift PAX-interacting protein 1 from Xenopus extracts prevented efficient PCNA ubiquitination
Title: PTIP/Swift is required for efficient PCNA ubiquitination in response to DNA damage.
PCNA monoubiquitylation serves as a molecular gas pedal that controls the speed of replisome movement during S phase.
Title: Ubiquitin/SUMO modification of PCNA promotes replication fork progression in Xenopus laevis egg extracts.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA polymerase processivity factor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within leading strand elongation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mismatch repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translesion synthesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of PCNA complex	IEA Inferred from Electronic Annotation more info
part_of PCNA-p21 complex	ISS Inferred from Sequence or Structural Similarity more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: proliferating cell nuclear antigen

Names: cyclin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087542.1 → NP_001081011.1 proliferating cell nuclear antigen

See identical proteins and their annotated locations for NP_001081011.1

Status: PROVISIONAL

Source sequence(s)

BC057758

UniProtKB/Swiss-Prot

P18248

UniProtKB/TrEMBL

A0A974D9H9, Q6PF20

Conserved Domains (2) summary

cd00577
Location:4 → 256

PCNA; Proliferating Cell Nuclear Antigen (PCNA) domain found in eukaryotes and archaea. These polymerase processivity factors play a role in DNA replication and repair. PCNA encircles duplex DNA in its central cavity, providing a DNA-bound platform for the ...

TIGR00590
Location:1 → 259

pcna; proliferating cell nuclear antigen (pcna)

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054376.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

30617838..30623298 complement

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GenBank, FASTA, Sequence Viewer (Graphics)