fen1.S flap structure-specific endonuclease 1 S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: fen1.S
Official Full Name: flap structure-specific endonuclease 1 S homeolog
Primary source: Xenbase:XB-GENE-6254462
Locus tag: XELAEV_18024332mg
See related: EnsemblRapid:ENSXLAG00005005572
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: mf1; fen1; rad2; fen-1; fen1-a; fen1-b
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Genomic context

Location:: chromosome: 4S

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	4S	NC_054378.1 (6737554..6740695)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	4S	NC_030731.1 (6569035..6572175)

Chromosome 4S - NC_054378.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables 5'-3' exonuclease activity	IEA Inferred from Electronic Annotation more info
enables 5'-flap endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables 5'-flap endonuclease activity	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA-DNA hybrid ribonuclease activity	IEA Inferred from Electronic Annotation more info
enables endonuclease activity	IEA Inferred from Electronic Annotation more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within DNA replication, removal of RNA primer	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within base-excision repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within base-excision repair	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in mitochondrion	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: flap endonuclease 1-B

Names: flap endonuclease 1; xFEN-1b

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087515.1 → NP_001080984.1 flap endonuclease 1-B

See identical proteins and their annotated locations for NP_001080984.1

Status: PROVISIONAL

Source sequence(s)

U68141

UniProtKB/Swiss-Prot

B7ZPB1, P70054

UniProtKB/TrEMBL

A0A974D016

Related

ENSXLAP00005016442.1, ENSXLAT00005016738.1

Conserved Domains (3) summary

cd09907
Location:221 → 290

H3TH_FEN1-Euk; H3TH domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease: Eukaryotic homologs

cd09867
Location:4 → 344

PIN_FEN1; PIN domain of Flap Endonuclease-1, a structure-specific, divalent-metal-ion dependent, 5' nuclease and homologs

PTZ00217
Location:1 → 359

PTZ00217; flap endonuclease-1; Provisional