sfrp1.L secreted frizzled-related protein 1 L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: sfrp1.L
Official Full Name: secreted frizzled-related protein 1 L homeolog
Primary source: Xenbase:XB-GENE-865777
Locus tag: XELAEV_18018658mg
See related: EnsemblRapid:ENSXLAG00005002840 AllianceGenome:Xenbase:XB-GENE-865777
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: frp; frp1; frzA; XfrzA; frp-1; sarp2; sfrp1; sfrp1-a
Summary: Predicted to enable G protein-coupled receptor activity and Wnt-protein binding activity. Predicted to act upstream of or within G protein-coupled receptor signaling pathway; Wnt signaling pathway; and cell differentiation. Predicted to be located in extracellular space and plasma membrane. Is expressed in anatomical system and primary germ layer. Orthologous to human SFRP1 (secreted frizzled related protein 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 3L

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	3L	NC_054375.1 (135006737..135024378, complement)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	3L	NC_030728.1 (119670142..119687809, complement)

Chromosome 3L - NC_054375.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

sfrp1 promotes cardiomyocyte differentiation in Xenopus via negative-feedback regulation of Wnt signalling.
Title: sfrp1 promotes cardiomyocyte differentiation in Xenopus via negative-feedback regulation of Wnt signalling.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables Wnt-protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within non-canonical Wnt signaling pathway	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: secreted frizzled-related protein 1 L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087488.1 → NP_001080957.1 secreted frizzled-related protein 1 L homeolog precursor

See identical proteins and their annotated locations for NP_001080957.1

Status: PROVISIONAL

Source sequence(s)

AF049908

UniProtKB/TrEMBL

A0A974DE36, Q9YI24

Related

ENSXLAP00005008473.1, ENSXLAT00005008599.1

Conserved Domains (2) summary

cd03580
Location:180 → 303

NTR_Sfrp1_like; NTR domain, Secreted frizzled-related protein (Sfrp) 1-like subfamily; composed of proteins similar to human Sfrp1, Sfrp2 and Sfrp5. Sfrps are soluble proteins containing an NTR domain C-terminal to a cysteine-rich Frizzled domain. They show diverse ...

cl02447
Location:48 → 172

CRD_FZ; CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

NC_054375.1 Reference Xenopus_laevis_v10.1 Primary Assembly

Range

135006737..135024378 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)