c4a.L complement C4A (Rodgers blood group) L homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: c4a.L
Official Full Name: complement C4A (Rodgers blood group) L homeolog
Primary source: Xenbase:XB-GENE-478885
Locus tag: XELAEV_18039156mg
See related: EnsemblRapid:ENSXLAG00005024284 AllianceGenome:Xenbase:XB-GENE-478885
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: c4; c4a
Summary: Predicted to enable endopeptidase inhibitor activity. Predicted to act upstream of or within complement activation. Predicted to be located in several cellular components, including axon; dendrite; and extracellular space. Human ortholog(s) of this gene implicated in Graves' disease; complement component 4a deficiency; renal cell carcinoma; systemic lupus erythematosus; and vitiligo. Orthologous to human C4A (complement C4A (Chido/Rodgers blood group)). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 8L

Exon count:: 41

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	8L	NC_054385.1 (65185816..65230661)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	8L	NC_030738.1 (51688509..51733381)

Chromosome 8L - NC_054385.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables endopeptidase inhibitor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within complement activation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in dendrite	IEA Inferred from Electronic Annotation more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info
located_in synapse	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: complement C4A (Rodgers blood group) L homeolog

Names: complement component 4A (Rodgers blood group) L homeolog; fourth component of complement

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087465.1 → NP_001080934.1 complement C4A (Rodgers blood group) L homeolog precursor

See identical proteins and their annotated locations for NP_001080934.1

Status: PROVISIONAL

Source sequence(s)

D78003

UniProtKB/TrEMBL

A0A974C709, Q91741

Related

ENSXLAP00005071993.1, ENSXLAT00005073540.1

Conserved Domains (8) summary

cd00017
Location:668 → 728

ANATO; Anaphylatoxin homologous domain; C3a, C4a and C5a anaphylatoxins are protein fragments generated enzymatically in serum during activation of complement molecules C3, C4, and C5. They induce smooth muscle contraction. These fragments are homologous to ...

cd02896
Location:983 → 1273

complement_C3_C4_C5; Proteins similar to C3, C4 and C5 of vertebrate complement. The vertebrate complement system, comprised of a large number of distinct plasma proteins, is an effector of both the acquired and innate immune systems. The point of convergence of the ...

cd03584
Location:1531 → 1681

NTR_complement_C4; NTR/C345C domain, complement C4 subfamily; The NTR domain found in complement C4 is also known as the C345C domain because it occurs at the C-terminus of complement C3, C4 and C5. Complement C4 is a key player in the activation of the component classical ...

pfam00207
Location:767 → 856

A2M; Alpha-2-macroglobulin family

pfam01835
Location:141 → 234

A2M_N; MG2 domain

pfam07677
Location:1424 → 1513

A2M_recep; A-macroglobulin receptor

pfam07678
Location:1037 → 1275

A2M_comp; A-macroglobulin complement component

pfam07703
Location:463 → 595

A2M_N_2; Alpha-2-macroglobulin family N-terminal region