U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

hmgcl 3-hydroxy-3-methylglutaryl-CoA lyase [ Danio rerio (zebrafish) ]

Gene ID: 394190, updated on 12-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
hmgclprovided by ZNC
Official Full Name
3-hydroxy-3-methylglutaryl-CoA lyaseprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-958
See related
Ensembl:ENSDARG00000021220 AllianceGenome:ZFIN:ZDB-GENE-040426-958
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:56248
Summary
Predicted to enable hydroxymethylglutaryl-CoA lyase activity. Predicted to be involved in ketone body biosynthetic process; leucine catabolic process; and lipid metabolic process. Predicted to be located in peroxisome. Is expressed in liver. Human ortholog(s) of this gene implicated in amino acid metabolic disorder. Orthologous to human HMGCL (3-hydroxy-3-methylglutaryl-CoA lyase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See hmgcl in Genome Data Viewer
Location:
chromosome: 17
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 17 NC_007128.7 (24855678..24866727, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 17 NC_007128.6 (24837277..24848326, complement)

Chromosome 17 - NC_007128.7Genomic Context describing neighboring genes Neighboring gene gap junction protein beta 10 Neighboring gene gap junction protein beta 3 Neighboring gene zinc finger and BTB domain containing 8A Neighboring gene UDP-galactose-4-epimerase

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. SpG and SpRY variants expand the CRISPR toolbox for genome editing in zebrafish. Liang F, et al. Nat Commun, 2022 Jun 14. PMID 35701400, Free PMC Article
  2. UPLC-TOF-MS/MS metabolomics analysis of zebrafish metabolism by spirotetramat. Zhang J, et al. Environ Pollut, 2020 Nov. PMID 32798906
  3. A gain-of-function screen in zebrafish identifies a guanylate cyclase with a role in neuronal degeneration. Maddison LA, et al. Mol Genet Genomics, 2009 May. PMID 19221799, Free PMC Article
  4. A monocarboxylate transporter required for hepatocyte secretion of ketone bodies during fasting. Hugo SE, et al. Genes Dev, 2012 Feb 1. PMID 22302940, Free PMC Article
  5. Feeding and food availability modulate brain-derived neurotrophic factor, an orexigen with metabolic roles in zebrafish. Blanco AM, et al. Sci Rep, 2020 Jul 1. PMID 32612127, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC56248

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables hydroxymethylglutaryl-CoA lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables hydroxymethylglutaryl-CoA lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables oxo-acid-lyase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in L-leucine catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ketone body biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in peroxisome IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
hydroxymethylglutaryl-CoA lyase, mitochondrial
Names
3-hydroxymethyl-3-methylglutaryl-CoA lyase
3-hydroxymethyl-3-methylglutaryl-Coenzyme A lyase (hydroxymethylglutaricaciduria)
NP_957509.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201215.1 → NP_957509.1  hydroxymethylglutaryl-CoA lyase, mitochondrial

    See identical proteins and their annotated locations for NP_957509.1

    Status: PROVISIONAL

    Source sequence(s)
    BC046023
    UniProtKB/TrEMBL
    Q7ZV32
    Related
    ENSDARP00000026028.7, ENSDART00000027957.8
    Conserved Domains (2) summary
    cd07938
    Location:50 → 323
    DRE_TIM_HMGL; 3-hydroxy-3-methylglutaryl-CoA lyase, catalytic TIM barrel domain
    pfam00682
    Location:47 → 321
    HMGL-like; HMGL-like

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007128.7 Reference GRCz11 Primary Assembly

    Range
    24855678..24866727 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous