aldh4a1 aldehyde dehydrogenase 4 family, member A1 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aldh4a1provided by ZNC
Official Full Name: aldehyde dehydrogenase 4 family, member A1provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1179
See related: Ensembl:ENSDARG00000038207 AllianceGenome:ZFIN:ZDB-GENE-040426-1179
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:63592
Summary: Predicted to enable 1-pyrroline-5-carboxylate dehydrogenase activity. Predicted to be involved in proline catabolic process to glutamate. Predicted to act upstream of or within proline metabolic process. Predicted to be located in mitochondrial matrix. Is expressed in several structures, including alar plate midbrain region; optic tectum; optic vesicle; pronephric duct; and yolk syncytial layer. Human ortholog(s) of this gene implicated in hyperprolinemia type 2. Orthologous to human ALDH4A1 (aldehyde dehydrogenase 4 family member A1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 11

Exon count:: 15

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (41936435..41960282)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (41324318..41348165)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables 1-pyrroline-5-carboxylate dehydrogenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables 1-pyrroline-5-carboxylate dehydrogenase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within proline catabolic process to glutamate	IEA Inferred from Electronic Annotation more info
involved_in proline catabolic process to glutamate	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within proline metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in mitochondrial matrix	IEA Inferred from Electronic Annotation more info
located_in mitochondrion	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial

Names: L-glutamate gamma-semialdehyde dehydrogenase; P5C dehydrogenase; aldehyde dehydrogenase 4A1; aldehyde dehydrogenase family 4 member A1

NP_957452.1

EC 1.2.1.88

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_201158.1 → NP_957452.1 delta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial precursor

See identical proteins and their annotated locations for NP_957452.1

Status: PROVISIONAL

Source sequence(s)

BC055155

UniProtKB/Swiss-Prot

Q7SY23

Related

ENSDARP00000142254.2, ENSDART00000173103.2

Conserved Domains (1) summary

cd07123
Location:25 → 546

ALDH_F4-17_P5CDH; Delta(1)-pyrroline-5-carboxylate dehydrogenase, ALDH families 4 and 17