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txnl1 thioredoxin-like 1 [ Danio rerio (zebrafish) ]

Gene ID: 394113, updated on 2-Nov-2024

Summary

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Official Symbol
txnl1provided by ZNC
Official Full Name
thioredoxin-like 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-701
See related
Ensembl:ENSDARG00000011921 AllianceGenome:ZFIN:ZDB-GENE-040426-701
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
TXNL; zgc:55368
Summary
Predicted to enable protein-disulfide reductase activity. Predicted to be involved in anatomical structure morphogenesis. Predicted to be active in cytosol. Is expressed in liver. Orthologous to human TXNL1 (thioredoxin like 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See txnl1 in Genome Data Viewer
Location:
chromosome: 21
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (918295..929448, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (812490..823639)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene ornithine decarboxylase antizyme 1b Neighboring gene uncharacterized LOC137488769 Neighboring gene asparaginyl-tRNA synthetase 1 Neighboring gene scavenger receptor class B, member 2c

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Defining hepatic dysfunction parameters in two models of fatty liver disease in zebrafish larvae. Howarth DL, et al. Zebrafish, 2013 Jun. PMID 23697887, Free PMC Article
  2. Ethanol metabolism and oxidative stress are required for unfolded protein response activation and steatosis in zebrafish with alcoholic liver disease. Tsedensodnom O, et al. Dis Model Mech, 2013 Sep. PMID 23798569, Free PMC Article
  3. Flavin Adenine Dinucleotide Depletion Caused by electron transfer flavoprotein subunit alpha Haploinsufficiency Leads to Hepatic Steatosis and Injury in Zebrafish. Park KH, et al. Hepatol Commun, 2021 Jun. PMID 34141984, Free PMC Article
  4. Palmitic Acid-Enriched Diet Induces Hepatic Steatosis and Injury in Adult Zebrafish. Park KH, et al. Zebrafish, 2019 Dec. PMID 31355732, Free PMC Article
  5. 3-ketodihydrosphingosine reductase mutation induces steatosis and hepatic injury in zebrafish. Park KH, et al. Sci Rep, 2019 Feb 4. PMID 30718751, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC55368

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in anatomical structure morphogenesis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
thioredoxin-like protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201138.2 → NP_957432.2  thioredoxin-like protein 1

    Status: VALIDATED

    Source sequence(s)
    BX511310
    UniProtKB/TrEMBL
    A0A8M1PFN4, F6NTA0
    Related
    ENSDARP00000114555.1, ENSDART00000133976.3
    Conserved Domains (2) summary
    cd02947
    Location:11 → 104
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam06201
    Location:126 → 268
    PITH; PITH domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    918295..929448 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_021468785.2 → XP_021324460.1  thioredoxin-like protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8M9PTR2
    Conserved Domains (2) summary
    cd02947
    Location:11 → 104
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam06201
    Location:124 → 227
    PITH; PITH domain
Nucleotide Protein Strain
Heading Accession and Version

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