U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

ap2m1b adaptor related protein complex 2 subunit mu 1b [ Danio rerio (zebrafish) ]

Gene ID: 394001, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
ap2m1bprovided by ZNC
Official Full Name
adaptor related protein complex 2 subunit mu 1bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1103
See related
Ensembl:ENSDARG00000033899 AllianceGenome:ZFIN:ZDB-GENE-040426-1103
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ap2m1; zgc:56643
Summary
Predicted to enable clathrin adaptor activity. Acts upstream of or within Wnt signaling pathway. Predicted to be located in clathrin-coated pit and plasma membrane. Predicted to be part of AP-2 adaptor complex. Predicted to be active in cytoplasmic vesicle. Human ortholog(s) of this gene implicated in autosomal dominant intellectual developmental disorder. Orthologous to human AP2M1 (adaptor related protein complex 2 subunit mu 1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See ap2m1b in Genome Data Viewer
Location:
chromosome: 18
Exon count:
14
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (45955005..45984585)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (45956972..45986567)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene arginyl aminopeptidase like 1 Neighboring gene dishevelled segment polarity protein 3 Neighboring gene microRNA 737 Neighboring gene uncharacterized LOC137488339 Neighboring gene matrix metallopeptidase 23bb Neighboring gene phosphate cytidylyltransferase 1A, choline b

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Identification and functional characterization of AP-2 complex subunit mu-A as a new member of antimicrobial protein. Gong Y, et al. Dev Comp Immunol, 2021 Aug. PMID 33848529
  2. In vivo analysis of formation and endocytosis of the Wnt/β-catenin signaling complex in zebrafish embryos. Hagemann AI, et al. J Cell Sci, 2014 Sep 15. PMID 25074807, Free PMC Article
  3. Quantitative proteomics analysis of zebrafish exposed to sub-lethal dosages of β-methyl-amino-L-alanine (BMAA). Frøyset AK, et al. Sci Rep, 2016 Jul 12. PMID 27404450, Free PMC Article
  4. Screen for genes differentially expressed during regeneration of the zebrafish caudal fin. Padhi BK, et al. Dev Dyn, 2004 Nov. PMID 15376328
  5. Zebrafish miR-1 and miR-133 shape muscle gene expression and regulate sarcomeric actin organization. Mishima Y, et al. Genes Dev, 2009 Mar 1. PMID 19240126, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • MGC56643

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables clathrin adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables lipid binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within Wnt signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in clathrin-dependent endocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within vesicle-mediated transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of AP-2 adaptor complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of clathrin adaptor complex IEA
Inferred from Electronic Annotation
more info
  
located_in clathrin-coated pit IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytoplasmic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
AP-2 complex subunit mu-B
Names
AP-2 complex subunit mu-1-B
AP-2 mu-2 chain B
AP-2 mu-B chain
adaptor-related protein complex 2, mu 1 subunit, b
clathrin assembly protein complex 2 medium chain B
clathrin assembly protein complex 2 mu-B medium chain
clathrin coat assembly protein AP50-B
clathrin coat-associated protein AP50-B
mu2-adaptin-B
plasma membrane adaptor AP-2 50 kDa protein B

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_201026.2 → NP_957320.1  AP-2 complex subunit mu-B

    See identical proteins and their annotated locations for NP_957320.1

    Status: PROVISIONAL

    Source sequence(s)
    BC049515
    UniProtKB/Swiss-Prot
    Q7ZW98
    Related
    ENSDARP00000126276.1, ENSDART00000151418.3
    Conserved Domains (1) summary
    cd09251
    Location:168 → 435
    AP-2_Mu2_Cterm; C-terminal domain of medium Mu2 subunit in ubiquitously expressed clathrin-associated adaptor protein (AP) complex AP-2

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    45955005..45984585
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_068214744.1 → XP_068070845.1  AP-2 complex subunit mu-B isoform X1

  2. XM_068214745.1 → XP_068070846.1  AP-2 complex subunit mu-B isoform X2

    Related
    ENSDARP00000126148.1, ENSDART00000151112.3
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7ZW98.1 GenPept UniProtKB/Swiss-Prot:Q7ZW98

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous