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app approximated [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39399, updated on 18-Sep-2024

Summary

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Official Symbol
appprovided by FlyBase
Official Full Name
approximatedprovided by FlyBase
Primary source
FLYBASE:FBgn0260941
Locus tag
Dmel_CG42318
See related
AllianceGenome:FB:FBgn0260941
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
App; APP; CG17144; CG42318; CG5620; CR32097; Dmel\CG42318
Old locus tag
Dmel_CG17144; Dmel_CG5620
Summary
Predicted to enable protein-cysteine S-palmitoyltransferase activity. Involved in establishment of body hair or bristle planar orientation; establishment of imaginal disc-derived wing hair orientation; and pattern specification process. Located in apical cortex and endoplasmic reticulum. Is expressed in several structures, including adult head; embryonic/larval gut; germ layer; and somatic muscle cell. Human ortholog(s) of this gene implicated in syndromic X-linked intellectual disability Raymond type. Orthologous to several human genes including ZDHHC14 (zinc finger DHHC-type palmitoyltransferase 14). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See app in Genome Data Viewer
Location:
69A2-69A4; 3-38 cM
Exon count:
15
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (12206238..12266841, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (12199338..12259941, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Adenylate kinase 1 Neighboring gene tRNA splicing endonuclease subunit 54 Neighboring gene long non-coding RNA:CR43991 Neighboring gene uncharacterized protein Neighboring gene Porphobilinogen synthase Neighboring gene Spermine synthase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in Drosophila. Zhao XL, et al. J Neurosci, 2010 Jan 27. PMID 20107079, Free PMC Article
  2. Reproductive activity triggers accelerated male mortality and decreases lifespan: genetic and gene expression determinants in Drosophila. Branco AT, et al. Heredity (Edinb), 2017 Mar. PMID 27731328, Free PMC Article
  3. The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat. Matakatsu H, et al. J Cell Biol, 2017 Jan 2. PMID 28031421, Free PMC Article
  4. The DHHC palmitoyltransferase approximated regulates Fat signaling and Dachs localization and activity. Matakatsu H, et al. Curr Biol, 2008 Sep 23. PMID 18804377, Free PMC Article
  5. Cytological location and further characterization of the Third chromosome resistance gene in Drosophila melanogaster. Bishop CP, et al. Genetica, 1999. PMID 10568256

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Concomitant loss of early girl and approximated results in accumulation of Dachs and Vamana in cytoplasmic punctae, suggesting that it also regulates their trafficking to the apical membrane.
    Title: Early girl is a novel component of the Fat signaling pathway.
  2. App promotes drosophila growth via the Hippo pathway by palmitoylation of Fat protein.
    Title: The palmitoyltransferase Approximated promotes growth via the Hippo pathway by palmitoylation of Fat.
  3. Consistent with its role in Psn processing, hibris genetically interacts with the Drosophila beta-amyloid protein precursor-like (Appl) protein.
    Title: Hibris, a Drosophila nephrin homolog, is required for presenilin-mediated Notch and APP-like cleavages.
  4. These results suggest that Abeta accumulation depletes presynaptic and axonal mitochondria, leading to other presynaptic deficits.
    Title: Expression of beta-amyloid induced age-dependent presynaptic and axonal changes in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein-cysteine S-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-cysteine S-palmitoyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
involved_in establishment of body hair or bristle planar orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in establishment of imaginal disc-derived wing hair orientation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in pattern specification process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical cortex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
approximated
Names
CG42318-PH
CG42318-PI
CG42318-PJ
CG42318-PK
CG42318-PL
CG42318-PM
CG42318-PO
CG42318-PR
CG42318-PS
CG42318-PT
app-PH
app-PI
app-PJ
app-PK
app-PL
app-PM
app-PO
app-PR
app-PS
app-PT
NP_001137936.1
NP_001137937.1
NP_001137938.2
NP_001137939.2
NP_001246731.2
NP_001246732.1
NP_001246733.2
NP_001287043.1
NP_648561.2
NP_996065.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    12206238..12266841 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001259803.2 → NP_001246732.1  approximated, isoform O [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246732.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NLJ6
    Conserved Domains (1) summary
    pfam01529
    Location:146 → 270
    DHHC; DHHC palmitoyltransferase

  2. NM_001144465.2 → NP_001137937.1  approximated, isoform M [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137937.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2VEY9, B7Z0A6, M9NDQ1, M9NF95
    Conserved Domains (1) summary
    pfam01529
    Location:146 → 272
    zf-DHHC; DHHC palmitoyltransferase

  3. NM_001144464.2 → NP_001137936.1  approximated, isoform L [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137936.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2VEY9, B7Z0A6, M9NDQ1, M9NF95
    Conserved Domains (1) summary
    pfam01529
    Location:146 → 272
    zf-DHHC; DHHC palmitoyltransferase

  4. NM_001300114.1 → NP_001287043.1  approximated, isoform T [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001287043.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2VEY9, B7Z0A6, M9NDQ1, M9NF95
    Conserved Domains (1) summary
    pfam01529
    Location:146 → 272
    zf-DHHC; DHHC palmitoyltransferase

  5. NM_001259802.2 → NP_001246731.2  approximated, isoform R [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246731.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2VEY9, B7Z0A6, M9NDQ1, M9NF95
    Conserved Domains (1) summary
    pfam01529
    Location:146 → 272
    zf-DHHC; DHHC palmitoyltransferase

  6. NM_001259804.2 → NP_001246733.2  approximated, isoform S [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001246733.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A2VEY9
    Conserved Domains (1) summary
    cl19890
    Location:18 → 53
    zf-DHHC; DHHC palmitoyltransferase

  7. NM_140304.7 → NP_648561.2  approximated, isoform K [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648561.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTV6
    Conserved Domains (1) summary
    pfam01529
    Location:146 → 270
    zf-DHHC; DHHC palmitoyltransferase

  8. NM_206343.5 → NP_996065.2  approximated, isoform J [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_996065.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VTV6
    Conserved Domains (1) summary
    pfam01529
    Location:146 → 270
    zf-DHHC; DHHC palmitoyltransferase

  9. NM_001144467.3 → NP_001137939.2  approximated, isoform I [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137939.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NLJ6
    Conserved Domains (1) summary
    pfam01529
    Location:146 → 270
    zf-DHHC; DHHC palmitoyltransferase

  10. NM_001144466.3 → NP_001137938.2  approximated, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001137938.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q6NLJ6
    Conserved Domains (1) summary
    pfam01529
    Location:146 → 270
    zf-DHHC; DHHC palmitoyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A2VEY9.1 A2VEY9
Q8SY85 Q8SY85
Q9VTV6 Q9VTV6

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