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usp20 ubiquitin specific peptidase 20 [ Danio rerio (zebrafish) ]

Gene ID: 393962, updated on 18-Sep-2024

Summary

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Official Symbol
usp20provided by ZNC
Official Full Name
ubiquitin specific peptidase 20provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1219
See related
Ensembl:ENSDARG00000027501 AllianceGenome:ZFIN:ZDB-GENE-040426-1219
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
zgc:63661; im:7151955
Summary
Predicted to enable cysteine-type endopeptidase activity and thiol-dependent deubiquitinase. Acts upstream of or within central nervous system morphogenesis and cranial skeletal system development. Predicted to be located in centrosome. Predicted to be active in cytoplasm. Is expressed in central nervous system and yolk syncytial layer. Orthologous to human USP20 (ubiquitin specific peptidase 20). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See usp20 in Genome Data Viewer
Location:
chromosome: 5
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 5 NC_007116.7 (33298700..33330479)
105 previous assembly GRCz10 (GCF_000002035.5) 5 NC_007116.6 (32698528..32730326)

Chromosome 5 - NC_007116.7Genomic Context describing neighboring genes Neighboring gene zgc:103692 Neighboring gene mediator complex subunit 22 Neighboring gene prostaglandin E synthase Neighboring gene GTPase activating Rap/RanGAP domain like 3

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Importance of deubiquitinases in zebrafish craniofacial development. Tse WKF. Biochem Biophys Res Commun, 2017 Jun 10. PMID 28450118
  2. Positive correlation between gene coexpression and positional clustering in the zebrafish genome. Ng YK, et al. BMC Genomics, 2009 Jan 22. PMID 19159490, Free PMC Article
  3. Genome-wide loss-of-function analysis of deubiquitylating enzymes for zebrafish development. Tse WK, et al. BMC Genomics, 2009 Dec 30. PMID 20040115, Free PMC Article
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC63661

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables cysteine-type deubiquitinase activity IEA
Inferred from Electronic Annotation
more info
  
enables cysteine-type deubiquitinase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type endopeptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables cysteine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables peptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within central nervous system morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cranial skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein K48-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in protein K63-linked deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within protein deubiquitination IEA
Inferred from Electronic Annotation
more info
  
involved_in protein deubiquitination ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within proteolysis IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of G protein-coupled receptor signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in centrosome IEA
Inferred from Electronic Annotation
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
ubiquitin carboxyl-terminal hydrolase 20
Names
deubiquitinating enzyme 20
ubiquitin specific protease 20
ubiquitin thioesterase 20
ubiquitin thiolesterase 20
ubiquitin-specific-processing protease 20
NP_957281.2
XP_009299732.1
XP_009299733.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200987.2 → NP_957281.2  ubiquitin carboxyl-terminal hydrolase 20

    See identical proteins and their annotated locations for NP_957281.2

    Status: PROVISIONAL

    Source sequence(s)
    CR382323
    UniProtKB/Swiss-Prot
    A5PN09
    Conserved Domains (5) summary
    smart00695
    Location:812 → 896
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:443 → 683
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:147 → 252
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:147 → 682
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:30 → 90
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007116.7 Reference GRCz11 Primary Assembly

    Range
    33298700..33330479
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009301458.4 → XP_009299733.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X2

    See identical proteins and their annotated locations for XP_009299733.1

    UniProtKB/Swiss-Prot
    A5PM59, A5PN09
    Related
    ENSDARP00000014964.8, ENSDART00000006021.9
    Conserved Domains (5) summary
    smart00695
    Location:810 → 894
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:443 → 683
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:147 → 252
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:147 → 682
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:30 → 90
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

  2. XM_009301457.3 → XP_009299732.1  ubiquitin carboxyl-terminal hydrolase 20 isoform X1

    UniProtKB/TrEMBL
    A0A8M3B2G6
    Conserved Domains (5) summary
    smart00695
    Location:843 → 927
    DUSP; Domain in ubiquitin-specific proteases
    cd02674
    Location:476 → 716
    Peptidase_C19R; A subfamily of peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...
    cl02553
    Location:180 → 285
    Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
    pfam00443
    Location:180 → 715
    UCH; Ubiquitin carboxyl-terminal hydrolase
    pfam02148
    Location:63 → 123
    zf-UBP; Zn-finger in ubiquitin-hydrolases and other protein

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018394588.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    8749..33231
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A5PN09.1 GenPept UniProtKB/Swiss-Prot:A5PN09

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