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ppp2cab protein phosphatase 2 catalytic subunit alpha b [ Danio rerio (zebrafish) ]

Gene ID: 393885, updated on 2-Nov-2024

Summary

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Official Symbol
ppp2cabprovided by ZNC
Official Full Name
protein phosphatase 2 catalytic subunit alpha bprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-877
See related
Ensembl:ENSDARG00000053404 AllianceGenome:ZFIN:ZDB-GENE-040426-877
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
Ppp2ca; zgc:56064
Summary
Predicted to enable protein serine/threonine phosphatase activity. Predicted to be involved in mitotic cell cycle. Predicted to be located in chromosome, centromeric region; nucleus; and spindle pole. Predicted to be active in cytosol. Orthologous to human PPP2CA (protein phosphatase 2 catalytic subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See ppp2cab in Genome Data Viewer
Location:
chromosome: 21
Exon count:
7
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 21 NC_007132.7 (45351660..45363871, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 21 NC_007132.6 (45310849..45323060, complement)

Chromosome 21 - NC_007132.7Genomic Context describing neighboring genes Neighboring gene transcription factor 7 Neighboring gene S-phase kinase-associated protein 1 Neighboring gene ubiquitin-conjugating enzyme E2B (RAD6 homolog) Neighboring gene CDKN2A interacting protein N-terminal like

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6. Xin Y, et al. Elife, 2019 Sep 17. PMID 31526479, Free PMC Article
  2. Evolution of complexity in the zebrafish synapse proteome. Bayés À, et al. Nat Commun, 2017 Mar 2. PMID 28252024, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

Clone Names

  • MGC56064

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoprotein phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cellular_component ND
No biological Data available
more info
  
located_in chromosome, centromeric region IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
Names
protein phosphatase 2a, catalytic subunit, alpha
NP_957205.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200911.3 → NP_957205.2  serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

    Status: VALIDATED

    Source sequence(s)
    FP017197
    UniProtKB/TrEMBL
    A0A8M9PI57, Q7ZVE7
    Related
    ENSDARP00000125818.1, ENSDART00000151106.3
    Conserved Domains (1) summary
    cd07415
    Location:9 → 293
    MPP_PP2A_PP4_PP6; PP2A, PP4, and PP6 phosphoprotein phosphatases, metallophosphatase domain

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007132.7 Reference GRCz11 Primary Assembly

    Range
    45351660..45363871 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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