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cep89 centrosomal protein 89 [ Danio rerio (zebrafish) ]

Gene ID: 393852, updated on 2-Nov-2024

Summary

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Official Symbol
cep89provided by ZNC
Official Full Name
centrosomal protein 89provided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1210
See related
Ensembl:ENSDARG00000005092 AllianceGenome:ZFIN:ZDB-GENE-040426-1210
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ccdc123; zgc:63648
Summary
Predicted to be involved in cilium assembly and mitochondrion organization. Predicted to act upstream of or within cell projection organization and chemical synaptic transmission. Predicted to be located in centrosome and spindle pole. Predicted to be part of ciliary transition fiber. Predicted to be active in centriole. Orthologous to human CEP89 (centrosomal protein 89). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See cep89 in Genome Data Viewer
Location:
chromosome: 7
Exon count:
21
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 7 NC_007118.7 (38395173..38503481)
105 previous assembly GRCz10 (GCF_000002035.5) 7 NC_007118.6 (38123943..38230414)

Chromosome 7 - NC_007118.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 7 member 10a Neighboring gene rhophilin, Rho GTPase binding protein 2 Neighboring gene zgc:165481 Neighboring gene solute carrier family 7 member 9 Neighboring gene nudix (nucleoside diphosphate linked moiety X)-type motif 19 Neighboring gene cugbp, Elav-like family member 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. The zebrafish cationic amino acid transporter/glycoprotein-associated family: sequence and spatiotemporal distribution during development of the transport system b(0,+) (slc3a1/slc7a9). Ellingsen S, et al. Fish Physiol Biochem, 2021 Oct. PMID 34338990, Free PMC Article
  2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC63648

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell projection organization IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within cilium assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cilium assembly ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in mitochondrion organization IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within mitochondrion organization IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in centriole IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in centriole IEA
Inferred from Electronic Annotation
more info
  
located_in centriole ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in centrosome ISS
Inferred from Sequence or Structural Similarity
more info
  
part_of ciliary transition fiber IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial intermembrane space IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  
located_in spindle pole ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
centrosomal protein of 89 kDa
Names
coiled-coil domain containing 123
coiled-coil domain-containing protein 123, mitochondrial

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001430965.1 → NP_001417894.1  centrosomal protein of 89 kDa

    Status: VALIDATED

    Source sequence(s)
    BX323855, BX571680

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007118.7 Reference GRCz11 Primary Assembly

    Range
    38395173..38503481
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_009303314.4 → XP_009301589.1  centrosomal protein of 89 kDa isoform X4

    UniProtKB/Swiss-Prot
    Q6P402
    UniProtKB/TrEMBL
    A0A8M3B481
    Conserved Domains (1) summary
    pfam14735
    Location:474 → 635
    HAUS4; HAUS augmin-like complex subunit 4

  2. XM_009303313.4 → XP_009301588.1  centrosomal protein of 89 kDa isoform X2

    UniProtKB/TrEMBL
    A0A8M2BGA9, A0A8M3AUC0
    Conserved Domains (1) summary
    pfam14735
    Location:411 → 572
    HAUS4; HAUS augmin-like complex subunit 4

  3. XM_017356830.3 → XP_017212319.1  centrosomal protein of 89 kDa isoform X1

    UniProtKB/TrEMBL
    A0A8M2BGA9, A0A8M6YZ50

  4. XM_005168973.5 → XP_005169030.2  centrosomal protein of 89 kDa isoform X3

    UniProtKB/Swiss-Prot
    Q6P402
    UniProtKB/TrEMBL
    A0A8M2BGA8
    Conserved Domains (2) summary
    COG1196
    Location:533 → 768
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR02169
    Location:277 → 648
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

  5. XM_068222198.1 → XP_068078299.1  centrosomal protein of 89 kDa isoform X5

  6. XM_068222199.1 → XP_068078300.1  centrosomal protein of 89 kDa isoform X7

  7. XM_009303315.4 → XP_009301590.1  centrosomal protein of 89 kDa isoform X6

    UniProtKB/Swiss-Prot
    Q6P402
    UniProtKB/TrEMBL
    A0A8M3B1B7
    Related
    ENSDARP00000121321.1, ENSDART00000138669.3
    Conserved Domains (1) summary
    pfam14735
    Location:474 → 635
    HAUS4; HAUS augmin-like complex subunit 4

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_200878.1: Suppressed sequence

    Description
    NM_200878.1: This RefSeq was removed because currently there is insufficient support for the transcript and the protein.
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6P402.1 GenPept UniProtKB/Swiss-Prot:Q6P402

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