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gnao1a guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a [ Danio rerio (zebrafish) ]

Gene ID: 393760, updated on 2-Nov-2024

Summary

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Official Symbol
gnao1aprovided by ZNC
Official Full Name
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-040426-1757
See related
Ensembl:ENSDARG00000016676 AllianceGenome:ZFIN:ZDB-GENE-040426-1757
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
gnao1; zgc:73315; wu:fq26h05
Summary
Predicted to enable G protein-coupled receptor binding activity; G-protein beta/gamma-subunit complex binding activity; and GTPase activity. Predicted to be involved in G protein-coupled dopamine receptor signaling pathway and adenylate cyclase-modulating G protein-coupled receptor signaling pathway. Predicted to act upstream of or within G protein-coupled receptor signaling pathway. Predicted to be part of heterotrimeric G-protein complex. Predicted to be active in cytoplasm. Is expressed in bone tissue; gill; nervous system; neural rod; and trigeminal placode. Human ortholog(s) of this gene implicated in developmental and epileptic encephalopathy 17 and neurodevelopmental disorder with involuntary movements. Orthologous to human GNAO1 (G protein subunit alpha o1). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
human mouse all
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Genomic context

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See gnao1a in Genome Data Viewer
Location:
chromosome: 18
Exon count:
10
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (22793401..22976664)
105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (22804071..22987598)

Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene nudix hydrolase 21 Neighboring gene heat shock transcription factor 4 Neighboring gene uncharacterized LOC108179979 Neighboring gene core-binding factor subunit beta Neighboring gene uncharacterized LOC137488280

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Differential role of Axin RGS domain function in Wnt signaling during anteroposterior patterning and maternal axis formation. Schneider PN, et al. PLoS One, 2012. PMID 22957046, Free PMC Article
  2. Effects of chronic ethanol administration on brain protein levels: a proteomic investigation using 2-D DIGE system. Damodaran S, et al. Eur J Pharmacol, 2006 Oct 10. PMID 16978605
  3. Identification of Molecular Targets for 4,5-Dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT) in Teleosts: New Insight into Mechanism of Toxicity. Chen L, et al. Environ Sci Technol, 2017 Feb 7. PMID 28026967
  4. Localization of genes encoding metallothionein-like protein (mt2 and smtb) in the brain of zebrafish. Teoh SL, et al. J Chem Neuroanat, 2015 Dec. PMID 26571427
  5. Prematurely terminated intron-retaining mRNAs invade axons in SFPQ null-driven neurodegeneration and are a hallmark of ALS. Taylor R, et al. Nat Commun, 2022 Nov 22. PMID 36414621, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Markers

Homology

Clone Names

  • MGC73315

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables G protein-coupled serotonin receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables G-protein beta/gamma-subunit complex binding IEA
Inferred from Electronic Annotation
more info
  
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
  
enables corticotropin-releasing hormone receptor 1 binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanyl nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables mu-type opioid receptor binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G protein-coupled dopamine receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in adenylate cyclase-modulating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within adenylate cyclase-modulating G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of heterotrimeric G-protein complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a
Names
Galpha o1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_200787.2 → NP_957081.1  guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a

    See identical proteins and their annotated locations for NP_957081.1

    Status: VALIDATED

    Source sequence(s)
    BX001001, BX088710, BX663522
    UniProtKB/TrEMBL
    A0A8M1PFR7, Q6PBP1
    Related
    ENSDARP00000124476.1, ENSDART00000149685.3
    Conserved Domains (1) summary
    cd00066
    Location:34 → 348
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007129.7 Reference GRCz11 Primary Assembly

    Range
    22793401..22976664
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005159069.5 → XP_005159126.1  guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O, a isoform X1

    UniProtKB/TrEMBL
    A0A8M2B616, F8W442
    Related
    ENSDARP00000124253.1, ENSDART00000150106.3
    Conserved Domains (2) summary
    cd00066
    Location:34 → 348
    G-alpha; Alpha subunit of G proteins (guanine nucleotide binding)
    smart00275
    Location:14 → 352
    G_alpha; G protein alpha subunit

Reference GRCz11 ALT_DRER_TU_1

Genomic

  1. NW_018395026.1 Reference GRCz11 ALT_DRER_TU_1

    Range
    38217..167354
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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