Aps Aps pyrophosphatase [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: Apsprovided by FlyBase
Official Full Name: Aps pyrophosphataseprovided by FlyBase
Primary source: FLYBASE:FBgn0036111
Locus tag: Dmel_CG6391
See related: AllianceGenome:FB:FBgn0036111
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: anon-WO0118547.266; CG6391; Dmel\CG6391
Summary: Enables bis(5'-adenosyl)-hexaphosphatase activity and inositol diphosphate pentakisphosphate diphosphatase activity. Involved in several processes, including glucose homeostasis; inositol phosphate metabolic process; and lipid homeostasis. Located in cytoplasm and nucleus. Is expressed in several structures, including embryonic Malpighian tubule; embryonic/larval midgut; extended germ band embryo; foregut primordium; and presumptive embryonic/larval system. Orthologous to several human genes including NUDT4 (nudix hydrolase 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: 67F1-67F1; 3-33 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (10894776..10899123, complement)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (10887876..10892223, complement)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Aps knockdown in Drosophila central nervous system, or the insulin-producing cells induces hyperinsulinemia-like phenotypes, including decrease in circulating trehalose levels as well as decreasing all carbohydrate levels under starvation conditions.
Title: The Obesity-Linked Gene Nudt3 Drosophila Homolog Aps Is Associated With Insulin Signaling.
These data suggest that the redox state of Aps may play a role in controlling its activity by altering its stability, something that could be important for regulating PP-InsP(5) during development.
Title: Oxidation of the diphosphoinositol polyphosphate phosphohydrolase-like Nudix hydrolase Aps from Drosophila melanogaster induces thermolability--A possible regulatory switch?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dm0973 (e-PCR)
- UniSTS:46294

Homology

NCBI Orthologs

Orthologs from OrthoDB

Gene Ontology Provided by FlyBase

Function	Evidence Code	Pubs
enables bis(5'-adenosyl)-hexaphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables bis(5'-adenosyl)-hexaphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables bis(5'-adenosyl)-pentaphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables diphosphoinositol-polyphosphate diphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables endopolyphosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol diphosphate pentakisphosphate diphosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables pyrophosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in adenosine 5'-(hexahydrogen pentaphosphate) catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine hexaphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diadenosine pentaphosphate catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in diphosphoinositol polyphosphate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in glucose homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in inositol phosphate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in lipid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in nucleotide metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Aps pyrophosphatase

Names: Aps-PA; Aps-PB; Aps-PC; CG6391-PA; CG6391-PB; CG6391-PC

NP_648421.1

EC 3.-.-.-

EC 3.6.1.10

EC 3.6.1.52

NP_729639.1

EC 3.-.-.-

EC 3.6.1.10

EC 3.6.1.52

NP_729640.1

EC 3.-.-.-

EC 3.6.1.10

EC 3.6.1.52

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NT_037436.4 Reference assembly

Range

10894776..10899123 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_168426.3 → NP_729640.1 Aps pyrophosphatase, isoform C [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729640.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JVG2

Related

FBpp0075981

Conserved Domains (1) summary

cd04666
Location:19 → 137

Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
NM_140164.4 → NP_648421.1 Aps pyrophosphatase, isoform A [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_648421.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JVG2

Related

FBpp0075979

Conserved Domains (1) summary

cd04666
Location:19 → 137

Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...
NM_168425.3 → NP_729639.1 Aps pyrophosphatase, isoform B [Drosophila melanogaster]

See identical proteins and their annotated locations for NP_729639.1

Status: REVIEWED

UniProtKB/TrEMBL

Q7JVG2

Related

FBpp0075980

Conserved Domains (1) summary

cd04666
Location:19 → 137

Nudix_Hydrolase_9; Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly ...