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iPLA2-VIA calcium-independent phospholipase A2 VIA [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39160, updated on 2-Nov-2024

Summary

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Official Symbol
iPLA2-VIAprovided by FlyBase
Official Full Name
calcium-independent phospholipase A2 VIAprovided by FlyBase
Primary source
FLYBASE:FBgn0036053
Locus tag
Dmel_CG6718
See related
AllianceGenome:FB:FBgn0036053
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG6718; diPLA2-VIA; Dmel\CG6718; iPLA2beta; iPLA[[2]]-VIA; PLA2G6
Summary
Enables retromer complex binding activity. Involved in positive regulation of response to oxidative stress; regulation of ceramide biosynthetic process; and triglyceride homeostasis. Located in mitochondrion. Is expressed in several structures, including adult head; central brain primordium; embryonic/larval garland cell; ganglia; and primordial germ cell. Used to study Parkinson's disease 14; neurodegeneration with brain iron accumulation 2a; and neurodegenerative disease. Human ortholog(s) of this gene implicated in dystonia 12; neuroaxonal dystrophy; and neurodegenerative disease (multiple). Orthologous to human PLA2G6 (phospholipase A2 group VI). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See iPLA2-VIA in Genome Data Viewer
Location:
67C11-67C11; 3-31 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9860217..9864349, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9853317..9857449, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Ras GTPase activating protein 1 Neighboring gene uncharacterized protein Neighboring gene Ciz1 zinc finger protein Neighboring gene long non-coding RNA:CR45406

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mitochondrial dysfunction and defects in lipid homeostasis as therapeutic targets in neurodegeneration with brain iron accumulation. Kinghorn KJ, et al. Rare Dis, 2016. PMID 27141409, Free PMC Article
  2. Psychomotor Behavior: A Practical Approach in Drosophila. Iliadi KG, et al. Front Psychiatry, 2016. PMID 27630583, Free PMC Article
  3. Exploring therapeutic strategies for infantile neuronal axonal dystrophy (INAD/PARK14). Lin G, et al. Elife, 2023 Jan 16. PMID 36645408, Free PMC Article
  4. Lipidome-wide (13)C flux analysis: a novel tool to estimate the turnover of lipids in organisms and cultures. Schlame M, et al. J Lipid Res, 2020 Jan. PMID 31712250, Free PMC Article
  5. A course-based undergraduate research experience examining neurodegeneration in Drosophila melanogaster teaches students to think, communicate, and perform like scientists. Delventhal R, et al. PLoS One, 2020. PMID 32282825, Free PMC Article

See all (67) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. iPLA2-VIA is required for healthy aging of neurons, muscle, and the female germline in Drosophila melanogaster.
    Title: iPLA2-VIA is required for healthy aging of neurons, muscle, and the female germline in Drosophila melanogaster.
  2. iPLA2-VIA binds the retromer subunits Vps35 and Vps26 and enhances retromer function to promote protein and lipid recycling. iPLA2-VIA regulates ceramide and sphingolipid metabolism.
    Title: Phospholipase PLA2G6, a Parkinsonism-Associated Gene, Affects Vps26 and Vps35, Retromer Function, and Ceramide Levels, Similar to α-Synuclein Gain.
  3. a role of ALDHs as major contributors to the homeostasis of pyridine nucleotides in plants
    Title: Mutations in the Drosophila homolog of human PLA2G6 give rise to age-dependent loss of psychomotor activity and neurodegeneration.
  4. our findings demonstrate that loss of normal PLA2G6 gene activity leads to lipid peroxidation, mitochondrial dysfunction and subsequent mitochondrial membrane abnormalities.
    Title: Loss of PLA2G6 leads to elevated mitochondrial lipid peroxidation and mitochondrial dysfunction.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables calcium-independent phospholipase A2 activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcium-independent phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables calcium-independent phospholipase A2 activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables long-chain fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables long-chain fatty acyl-CoA hydrolase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables retromer complex binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables serine hydrolase activity HDA PubMed 
Process Evidence Code Pubs
involved_in cardiolipin acyl-chain remodeling ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of response to oxidative stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ceramide biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of sphingolipid biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in triglyceride homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
calcium-independent phospholipase A2 VIA
Names
CG6718-PA
CG6718-PB
CG6718-PC
CG6718-PD
iPLA2-VIA-PA
iPLA2-VIA-PB
iPLA2-VIA-PC
iPLA2-VIA-PD
phospholipase A[[2]]
NP_648366.2
NP_729565.2
NP_729566.2
NP_729567.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9860217..9864349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140109.2 → NP_648366.2  calcium-independent phospholipase A2 VIA, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648366.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R25, Q9VT60
    Related
    FBpp0076091
    Conserved Domains (4) summary
    cd07212
    Location:553 → 866
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:281 → 402
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:287 → 376
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:282 → 310
    ANK; ANK repeat [structural motif]

  2. NM_168383.2 → NP_729565.2  calcium-independent phospholipase A2 VIA, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729565.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R25, Q7KUD4
    Related
    FBpp0076092
    Conserved Domains (4) summary
    cd07212
    Location:563 → 876
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:291 → 412
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:297 → 386
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:292 → 320
    ANK; ANK repeat [structural motif]

  3. NM_168385.2 → NP_729567.2  calcium-independent phospholipase A2 VIA, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729567.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R25, Q7KUD4
    Related
    FBpp0076094
    Conserved Domains (4) summary
    cd07212
    Location:563 → 876
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:291 → 412
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:297 → 386
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:292 → 320
    ANK; ANK repeat [structural motif]

  4. NM_168384.2 → NP_729566.2  calcium-independent phospholipase A2 VIA, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729566.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q29R25, Q7KUD4
    Related
    FBpp0076093
    Conserved Domains (4) summary
    cd07212
    Location:563 → 876
    Pat_PNPLA9; Patatin-like phospholipase domain containing protein 9
    cd00204
    Location:291 → 412
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:297 → 386
    Ank_2; Ankyrin repeats (3 copies)
    sd00045
    Location:292 → 320
    ANK; ANK repeat [structural motif]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KUD4 Q7KUD4
Q8MR13 Q8MR13
Q9VT60 Q9VT60

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