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Jarid2 Jumonji, AT rich interactive domain 2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39103, updated on 2-Nov-2024

Summary

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Official Symbol
Jarid2provided by FlyBase
Official Full Name
Jumonji, AT rich interactive domain 2provided by FlyBase
Primary source
FLYBASE:FBgn0036004
Locus tag
Dmel_CG3654
See related
AllianceGenome:FB:FBgn0036004
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG3654; dJARID2; djmj; dJmj; Dmel\CG3654; jarid2; JARID2; l(3)j2B8
Summary
Predicted to enable DNA binding activity. Involved in chromatin remodeling and positive regulation of DNA-templated transcription. Located in euchromatin and nucleus. Is expressed in embryonic brain; embryonic/larval midgut; larval ventral nerve cord; organism; and spermatozoon. Human ortholog(s) of this gene implicated in autistic disorder. Orthologous to human JARID2 (jumonji and AT-rich interaction domain containing 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Jarid2 in Genome Data Viewer
Location:
67B9-67B10; 3-29 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (9477038..9486530)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (9470138..9479630)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Ubiquitin carboxy-terminal hydrolase L5 Neighboring gene pallbearer Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of dJmj differentially affects intestinal stem cells and differentiated enterocytes. Suong DNA, et al. Cell Signal, 2018 Jan. PMID 29102770
  2. Jarid2 Methylation via the PRC2 Complex Regulates H3K27me3 Deposition during Cell Differentiation. Sanulli S, et al. Mol Cell, 2015 Mar 5. PMID 25620564, Free PMC Article
  3. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease. Basu M, et al. JCI Insight, 2017 Oct 19. PMID 29046480, Free PMC Article
  4. The effects of genetic background on exercise performance in Drosophila. Damschroder D, et al. Fly (Austin), 2020 Mar-Dec. PMID 33100141, Free PMC Article
  5. Ex vivo genome-wide RNAi screening of the Drosophila Toll signaling pathway elicited by a larva-derived tissue extract. Kanoh H, et al. Biochem Biophys Res Commun, 2015 Nov 13. PMID 26427875

See all (73) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Overexpression of dJmj differentially affects intestinal stem cells and differentiated enterocytes.
    Title: Overexpression of dJmj differentially affects intestinal stem cells and differentiated enterocytes.
  2. in vivo studies with Jarid2 mutants in flies demonstrate that among several histone modifications tested, only methylation of histone 3 at K27 (H3K27), the mark implemented by PRC2, was affected
    Title: Polycomb repressive complex 2-dependent and -independent functions of Jarid2 in transcriptional regulation in Drosophila.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
NOT enables histone demethylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
NOT enables histone demethylase activity IKR
Inferred from Key Residues
more info
 PubMed 
NOT enables histone demethylase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables protein-containing complex binding IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in chromatin remodeling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in chromatin IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm HDA PubMed 
located_in euchromatin IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Jumonji, AT rich interactive domain 2
Names
CG3654-PD
Jarid2-PD
Jumonji, AT-rich interactive domain 2
jumonji

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    9477038..9486530
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140067.2 → NP_648324.1  Jumonji, AT rich interactive domain 2 [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648324.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9VT00
    Related
    FBpp0076196
    Conserved Domains (4) summary
    smart00545
    Location:1740 → 1781
    JmjN; Small domain found in the jumonji family of transcription factors
    pfam02373
    Location:2066 → 2181
    JmjC; JmjC domain, hydroxylase
    pfam01388
    Location:1812 → 1893
    ARID; ARID/BRIGHT DNA binding domain
    pfam02928
    Location:2281 → 2334
    zf-C5HC2; C5HC2 zinc finger
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q6AWH4 Q6AWH4
Q8SXP6 Q8SXP6
Q9VT00 Q9VT00

Gene LinkOut

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