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GUCY2EP guanylate cyclase 2E, pseudogene [ Homo sapiens (human) ]

Gene ID: 390226, updated on 17-Sep-2024

Summary

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Official Symbol
GUCY2EPprovided by HGNC
Official Full Name
guanylate cyclase 2E, pseudogeneprovided by HGNC
Primary source
HGNC:HGNC:4690
See related
MIM:601138; AllianceGenome:HGNC:4690
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GCD; GC-E; GUCY2E
Summary
This olfactory specific guanylyl cyclase is part of the mammalian olfactory system and and encodes a protein involved in chemosensation in rodents. The gene has become inactivated to become a pseudogene is humans and most primates. [provided by RefSeq, Oct 2008]
Expression
Low expression observed in reference dataset See more
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Genomic context

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See GUCY2EP in Genome Data Viewer
Location:
11q13.5
Exon count:
20
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (76680166..76721789, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (76610644..76652109, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (76391210..76432833, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:76319836-76320534 Neighboring gene long intergenic non-protein coding RNA 2757 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5292 Neighboring gene Sharpr-MPRA regulatory region 5087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5293 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76364813-76365336 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5294 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3784 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5296 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3785 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3786 Neighboring gene leucine rich repeat containing 32 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3787 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5297 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5298 Neighboring gene Sharpr-MPRA regulatory region 9026 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76399698-76400650 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:76409236-76409816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:76409817-76410395 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76410396-76410975 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76419008-76419508 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:76421157-76421658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:76432679-76433270 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3788 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:76456551-76456863 Neighboring gene uncharacterized LOC105369397 Neighboring gene uncharacterized LOC124902719

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Novel functions of photoreceptor guanylate cyclases revealed by targeted deletion. Karan S, et al. Mol Cell Biochem, 2010 Jan. PMID 20012162, Free PMC Article
  2. Degeneration of the olfactory guanylyl cyclase D gene during primate evolution. Young JM, et al. PLoS One, 2007 Sep 12. PMID 17849013, Free PMC Article
  3. Two eye guanylyl cyclases are expressed in the same photoreceptor cells and form homomers in preference to heteromers. Yang RB, et al. J Biol Chem, 1997 May 23. PMID 9153227
  4. Chromosomal localization and genomic organization of genes encoding guanylyl cyclase receptors expressed in olfactory sensory neurons and retina. Yang RB, et al. Genomics, 1996 Feb 1. PMID 8838319
  5. Comparative genomics search for losses of long-established genes on the human lineage. Zhu J, et al. PLoS Comput Biol, 2007 Dec. PMID 18085818, Free PMC Article

GeneRIFs: Gene References Into Functions

Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Other Names

  • olfactory guanylate cyclase

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_024042.2 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AP001189

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

    Range
    76680166..76721789 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060935.1 Alternate T2T-CHM13v2.0

    Range
    76610644..76652109 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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Chemical Information
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