U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

orb2 orb2 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 39018, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
orb2provided by FlyBase
Official Full Name
orb2provided by FlyBase
Primary source
FLYBASE:FBgn0264307
Locus tag
Dmel_CG43782
See related
AllianceGenome:FB:FBgn0264307
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0140519.222; CG43113; CG43782; cg5735; CG5735; Dmel\CG43782; Orb2; Orb2A; Orb2B
Old locus tag
Dmel_CG43113; Dmel_CG5735; Dmel_CG5741
Summary
Enables identical protein binding activity; mRNA 3'-UTR binding activity; and translation regulator activity, nucleic acid binding. Involved in several processes, including long-term memory; male gamete generation; and regulation of translation. Located in several cellular components, including axon terminus; dendrite terminus; and perinuclear region of cytoplasm. Part of protein-containing complex. Is expressed in several structures, including aCC neuron; central nervous system; ganglion mother cell GMC4-2a; gonad; and mesoderm. Orthologous to several human genes including CPEB4 (cytoplasmic polyadenylation element binding protein 4). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See orb2 in Genome Data Viewer
Location:
66E4-66E5; 3-27 cM
Exon count:
8
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (8937100..8954463, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (8930200..8947563, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene misfire Neighboring gene long non-coding RNA:CR43970 Neighboring gene Tetraspanin 66E Neighboring gene uncharacterized protein Neighboring gene Gram-negative bacteria binding protein 3 Neighboring gene mitochondrial ribosomal protein L12

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Long-Term Memory Formation in Drosophila Depends on the 3'UTR of CPEB Gene orb2. Kozlov EN, et al. Cells, 2023 Jan 14. PMID 36672258, Free PMC Article
  2. Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like β-sheets. Bowler JT, et al. J Biol Chem, 2022 Oct. PMID 35988647, Free PMC Article
  3. Prevalence and species distribution of the low-complexity, amyloid-like, reversible, kinked segment structural motif in amyloid-like fibrils. Hughes MP, et al. J Biol Chem, 2021 Oct. PMID 34537246, Free PMC Article
  4. Droplet and fibril formation of the functional amyloid Orb2. Ashami K, et al. J Biol Chem, 2021 Jul. PMID 34044018, Free PMC Article
  5. Divergent CPEB prion-like domains reveal different assembly mechanisms for a generic amyloid-like fold. Hervás R, et al. BMC Biol, 2021 Mar 11. PMID 33706787, Free PMC Article

See all (99) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation.
    Title: Orb2 enables rare-codon-enriched mRNA expression during Drosophila neuron differentiation.
  2. Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
    Title: Mrj is a chaperone of the Hsp40 family that regulates Orb2 oligomerization and long-term memory in Drosophila.
  3. Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like beta-sheets.
    Title: Micro-electron diffraction structure of the aggregation-driving N terminus of Drosophila neuronal protein Orb2A reveals amyloid-like β-sheets.
  4. The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis.
    Title: The 3'UTR of the Drosophila CPEB translation factor gene orb2 plays a crucial role in spermatogenesis.
  5. Droplet and fibril formation of the functional amyloid Orb2.
    Title: Droplet and fibril formation of the functional amyloid Orb2.
  6. Implications of the Orb2 Amyloid Structure in Huntington's Disease.
    Title: Implications of the Orb2 Amyloid Structure in Huntington's Disease.
  7. We present here evidences of a novel genetic mechanism to regulate synapse fine tuning during development and propose an equilibrium between Orb2 conformational state and nervous system formation.
    Title: Orb2 as modulator of Brat and their role at the neuromuscular junction.
  8. The N-terminus of Orb2A not only promotes the formation of fibrils, but also forms the fibril core.
    Title: Identification and Structural Characterization of the N-terminal Amyloid Core of Orb2 isoform A.
  9. Data confirm the original hypothesis that the glutamine, histidine-rich (Q/H-rich) domain of Orb2 can bind to transition metals via its His residues. Hence, the Q/H rich domain behaves like other H-rich domains, most of which were shown to be metal binding domains.
    Title: Metal Binding Properties of the N-Terminus of the Functional Amyloid Orb2.
  10. Study showed that the N-terminus specific to Orb2A can bind to lipid membranes; binding occurs preferentially to curved membranes and requires the membranes to be negatively charged. When binding to lipid membranes, the N-terminus of Orb2A undergoes a transition from a dynamic, intrinsically disordered state to a less dynamic alpha-helix. This lipid membrane interaction can prevent the N-terminus from forming amyloid f...
    Title: The Functional Amyloid Orb2A Binds to Lipid Membranes.
Submit: New GeneRIF Correction See all GeneRIFs (18)

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables RNA binding ISM
Inferred from Sequence Model
more info
 PubMed 
enables RNA binding NAS
Non-traceable Author Statement
more info
 PubMed 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA 3'-UTR binding IEA
Inferred from Electronic Annotation
more info
  
enables mRNA regulatory element binding translation repressor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables mRNA regulatory element binding translation repressor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA regulatory element binding translation repressor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ribosome binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation activator activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables translation factor activity, RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in asymmetric cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in long-term memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male courtship behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in male meiosis I IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of cytoplasmic translation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of translation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein stabilization IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of translation IEA
Inferred from Electronic Annotation
more info
  
involved_in sperm axoneme assembly IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sperm individualization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spermatogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in axon terminus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm HDA PubMed 
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in dendrite terminus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in perinuclear region of cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
is_active_in presynapse IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in presynapse IMP
Inferred from Mutant Phenotype
more info
 PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in synapse IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synapse IDA
Inferred from Direct Assay
more info
 PubMed 
located_in synaptic membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
orb2
Names
CG43782-PA
CG43782-PB
CG43782-PC
CG43782-PD
CG43782-PH
CG43782-PJ
CG43782-PK
cg43782 gene product from transcript cg43782-rh
orb2-PA
orb2-PB
orb2-PC
orb2-PD
orb2-PH
orb2-PJ
orb2-PK

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    8937100..8954463 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_140009.3 → NP_648266.1  orb2, isoform H [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648266.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95T31, Q9VSR2, Q9VSR3
    UniProtKB/TrEMBL
    A4V1P2
    Conserved Domains (4) summary
    COG0724
    Location:446 → 509
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:447 → 538
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:555 → 635
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:630 → 691
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  2. NM_001274679.1 → NP_001261608.1  orb2, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001261608.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95T31, Q9VSR2, Q9VSR3
    UniProtKB/TrEMBL
    A4V1P2
    Conserved Domains (4) summary
    COG0724
    Location:446 → 509
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:447 → 538
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:555 → 635
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:630 → 691
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  3. NM_001370022.1 → NP_001356977.1  orb2, isoform J [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K616
    Conserved Domains (3) summary
    cd12724
    Location:447 → 538
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:555 → 635
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:630 → 691
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  4. NM_001370023.1 → NP_001356978.1  orb2, isoform K [Drosophila melanogaster]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A4D6K784
    Conserved Domains (3) summary
    cd12724
    Location:447 → 538
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:555 → 635
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:630 → 691
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  5. NM_168300.3 → NP_729427.1  orb2, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729427.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95T31, Q9VSR2, Q9VSR3
    UniProtKB/TrEMBL
    A4V1P2
    Conserved Domains (4) summary
    COG0724
    Location:446 → 509
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:447 → 538
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:555 → 635
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:630 → 691
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  6. NM_168301.3 → NP_729428.1  orb2, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729428.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q95T31, Q9VSR2, Q9VSR3
    UniProtKB/TrEMBL
    A4V1P2
    Conserved Domains (4) summary
    COG0724
    Location:446 → 509
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:447 → 538
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:555 → 635
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:630 → 691
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain

  7. NM_168302.3 → NP_729429.1  orb2, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_729429.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9VSR3
    Conserved Domains (4) summary
    COG0724
    Location:293 → 356
    RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
    cd12724
    Location:294 → 385
    RRM1_CPEB2_like; RNA recognition motif 1 in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    cd12726
    Location:402 → 482
    RRM2_CPEB2_like; RNA recognition motif 2 found in cytoplasmic polyadenylation element-binding protein CPEB-2, CPEB-3, CPEB-4 and similar protiens
    pfam16366
    Location:477 → 538
    CEBP_ZZ; Cytoplasmic polyadenylation element-binding protein ZZ domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0A4D6K616 A0A4D6K616
A0A4D6K784 A0A4D6K784
A4V1P2 A4V1P2
Q9VSR3.1 Q9VSR3

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Molecular Biology Databases
Research Materials