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PF3D7_0623200 ferredoxin--NADP reductase [ Plasmodium falciparum 3D7 ]

Gene ID: 3885862, updated on 12-Sep-2024

Summary

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Gene symbol
PF3D7_0623200
Gene description
ferredoxin--NADP reductase
Locus tag
PF3D7_0623200
See related
PlasmoDB:PF3D7_0623200; VEuPathDB:PF3D7_0623200
Gene type
protein coding
RNA name
ferredoxin--NADP reductase
RefSeq status
PROVISIONAL
Organism
Plasmodium falciparum 3D7 (isolate: 3D7)
Lineage
Eukaryota; Sar; Alveolata; Apicomplexa; Aconoidasida; Haemosporida; Plasmodiidae; Plasmodium; Plasmodium (Laverania)
Orthologs
all
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Genomic context

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See PF3D7_0623200 in Genome Data Viewer
Location:
chromosome: 6
Exon count:
1
Sequence:
Chromosome: 6; NC_004327.3 (946129..947244)

Chromosome 6 - NC_004327.3Genomic Context describing neighboring genes Neighboring gene chorismate synthase Neighboring gene nuclear polyadenylated RNA-binding protein NAB2, putative Neighboring gene EGF-like membrane protein, putative Neighboring gene MEI2-like RNA-binding protein, putative

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_004327.3

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Covalent inhibition of P. falciparum ferredoxin-NADP(+) reductase: Exploring alternative strategies for the development of new antimalarial drugs.
    Title: Covalent inhibition of P. falciparum ferredoxin-NADP(+) reductase: Exploring alternative strategies for the development of new antimalarial drugs.
  2. Reactions of Plasmodium falciparum Ferredoxin:NADP(+) Oxidoreductase with Redox Cycling Xenobiotics: A Mechanistic Study.
    Title: Reactions of Plasmodium falciparum Ferredoxin:NADP(+) Oxidoreductase with Redox Cycling Xenobiotics: A Mechanistic Study.
  3. because the Y258F replacement increased the K(m) for NADPH 4-fold and decreased that for NADH 3-fold, it led to a drop in the ability of the enzyme to discriminate between the coenzymes from 70- to just 1.5-fold.
    Title: A single tyrosine hydroxyl group almost entirely controls the NADPH specificity of Plasmodium falciparum ferredoxin-NADP+ reductase.
  4. The His286 side chain of ferredoxin-NADP+ reductase plays a dual role in catalysis both by providing binding energy for NADPH and by favoring the catalytically competent orientation of its nicotinamide ring.
    Title: Plasmodium falciparum ferredoxin-NADP+ reductase His286 plays a dual role in NADP(H) binding and catalysis.
Submit: New GeneRIF Correction

General gene information

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Homology

Gene Ontology Provided by GeneDB

Function Evidence Code Pubs
enables electron transfer activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferredoxin-NAD(P) reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ferredoxin-NADP+ reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to xenobiotic stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in apicoplast HDA PubMed 
located_in apicoplast IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ferredoxin--NADP reductase
XP_966214.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_004327.3 Reference assembly

    Range
    946129..947244
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_961121.1 → XP_966214.1  ferredoxin--NADP reductase [Plasmodium falciparum 3D7]

    See identical proteins and their annotated locations for XP_966214.1

    Status: PROVISIONAL

    UniProtKB/Swiss-Prot
    C6KT68
    UniProtKB/TrEMBL
    A0A024V9Q7, A0A024VHL3, A0A024WAK7, A0A024WT45, A0A024XC48, A0A0L1IFM6, A0A0L7K7V3, W4ILT2, W4IUT0, W7FGL3, W7FM66, W7JS75, W7K8J5
    Conserved Domains (1) summary
    cd06208
    Location:63 → 371
    CYPOR_like_FNR; These ferredoxin reductases are related to the NADPH cytochrome p450 reductases (CYPOR), but lack the FAD-binding region connecting sub-domain. Ferredoxin-NADP+ reductase (FNR) is an FAD-containing enzyme that catalyzes the reversible electron transfer ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
C6KT68.1

Gene LinkOut

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Molecular Biology Databases
Research Materials