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SMSr Sphingomyelin synthase related [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38823, updated on 18-Sep-2024

Summary

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Official Symbol
SMSrprovided by FlyBase
Official Full Name
Sphingomyelin synthase relatedprovided by FlyBase
Primary source
FLYBASE:FBgn0052380
Locus tag
Dmel_CG32380
See related
AllianceGenome:FB:FBgn0052380
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG32380; CG8572; CG8576; Css3beta; Dmel\CG32380; dmSMSr; dSMSr
Summary
Enables ceramide cholinephosphotransferase activity and sphingomyelin synthase activity. Involved in ceramide biosynthetic process and regulation of ceramide biosynthetic process. Is integral component of endoplasmic reticulum membrane. Is expressed in adult head and organism. Orthologous to human SAMD8 (sterile alpha motif domain containing 8). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
all
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Genomic context

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See SMSr in Genome Data Viewer
Location:
65F7-65F9; 3-20 cM
Exon count:
4
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (7374050..7381474, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (7367150..7374574, complement)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Sh3beta Neighboring gene akirin Neighboring gene smallminded Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The multigenic sphingomyelin synthase family. Tafesse FG, et al. J Biol Chem, 2006 Oct 6. PMID 16905542
  2. Ceramide phosphoethanolamine, an enigmatic cellular membrane sphingolipid. Panevska A, et al. Biochim Biophys Acta Biomembr, 2019 Jul 1. PMID 31067435
  3. Ceramide phosphoethanolamine biosynthesis in Drosophila is mediated by a unique ethanolamine phosphotransferase in the Golgi lumen. Vacaru AM, et al. J Biol Chem, 2013 Apr 19. PMID 23449981, Free PMC Article
  4. Sphingomyelin synthase-related protein SMSr controls ceramide homeostasis in the ER. Vacaru AM, et al. J Cell Biol, 2009 Jun 15. PMID 19506037, Free PMC Article
  5. Endogenous ceramide phosphoethanolamine modulates circadian rhythm via neural-glial coupling in Drosophila. Chen X, et al. Natl Sci Rev, 2022 Dec. PMID 36713590, Free PMC Article

See all (35) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables ceramide cholinephosphotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ceramide cholinephosphotransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphotransferase activity, for other substituted phosphate groups IEA
Inferred from Electronic Annotation
more info
  
enables sphingomyelin synthase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables sphingomyelin synthase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of ceramide biosynthetic process IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in sphingomyelin biosynthetic process NAS
Non-traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
is_active_in Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane NAS
Non-traceable Author Statement
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
sphingomyelin synthase related
Names
CG32380-PA
CPE synthase
SMSr-PA
NP_648114.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    7374050..7381474 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139857.3 → NP_648114.1  sphingomyelin synthase related [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_648114.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q961G5, Q9VS60, Q9VS61
    Related
    FBpp0076580
    Conserved Domains (2) summary
    cd09515
    Location:55 → 126
    SAM_SGMS1-like; SAM domain of sphingomyelin synthase related subfamily
    pfam14360
    Location:349 → 422
    PAP2_C; PAP2 superfamily C-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VS60.2 Q9VS60

Gene LinkOut

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