melt melted [Drosophila melanogaster (fruit fly)] - Gene

Summary

Official Symbol: meltprovided by FlyBase
Official Full Name: meltedprovided by FlyBase
Primary source: FLYBASE:FBgn0023001
Locus tag: Dmel_CG8624
See related: AllianceGenome:FB:FBgn0023001
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Drosophila melanogaster
Lineage: Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as: 1441/14; anon-WO03014152.10; CG8624; dMelt; Dmel\CG8624; Melt; Q9VS24_DROME
Summary: Enables phosphatidylinositol-5-phosphate binding activity. Involved in several processes, including R8 cell fate specification; negative regulation of DNA-binding transcription factor activity; and positive regulation of signal transduction. Located in plasma membrane. Is expressed in several structures, including ectoderm; lateral cord neurons; photoreceptor cell R8 of pale ommatidium; ventral furrow; and ventral nerve cord primordium. Orthologous to human VEPH1 (ventricular zone expressed PH domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Annotation release	Status	Assembly	Chr	Location
Release 6.54	current	Release 6 plus ISO1 MT (GCF_000001215.4)	3L	NT_037436.4 (7134516..7143074)
Release 5.57	previous assembly	Release 5 (GCF_000001215.2)	3L	NT_037436.3 (7127616..7136174)

Chromosome 3L - NT_037436.4 Genomic Context describing neighboring genes

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Function	Evidence Code	Pubs
enables phosphatidylinositol binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol-5-phosphate binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol-5-phosphate binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in R8 cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cell fate specification	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of TORC1 signaling	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of signal transduction	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

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The following sections contain reference sequences that belong to a specific genome build. Explain