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tph1.L tryptophan hydroxylase 1 L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 387560, updated on 4-Nov-2024

Summary

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Official Symbol
tph1.L
Official Full Name
tryptophan hydroxylase 1 L homeolog
Primary source
Xenbase:XB-GENE-996927
Locus tag
XELAEV_18021665mg
See related
EnsemblRapid:ENSXLAG00005019012 AllianceGenome:Xenbase:XB-GENE-996927
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
tph; tph1; tph1.S
Summary
Predicted to enable iron ion binding activity and tryptophan 5-monooxygenase activity. Predicted to act upstream of or within platelet degranulation; regulation of hemostasis; and serotonin biosynthetic process. Predicted to be located in neuron projection. Is expressed in dermal system; nervous system; and visual system. Human ortholog(s) of this gene implicated in several diseases, including alcohol use disorder; attention deficit hyperactivity disorder; borderline personality disorder; depressive disorder (multiple); and scoliosis. Orthologous to human TPH1 (tryptophan hydroxylase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tph1.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
11
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (491782..500495, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (494597..503445, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene potassium voltage-gated channel subfamily C member 1 Neighboring gene myogenic differentiation 1 L homeolog Neighboring gene secretion regulating guanine nucleotide exchange factor L homeolog Neighboring gene uncharacterized LOC108713700 Neighboring gene serum amyloid A like 1 L homeolog Neighboring gene general transcription factor IIH subunit 1 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Tryptophan hydroxylase expression is regulated by a circadian clock in Xenopus laevis retina. Green CB, et al. J Neurochem, 1994 Jun. PMID 8189245

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables tryptophan 5-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within aromatic amino acid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within platelet degranulation ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within regulation of hemostasis ISS
Inferred from Sequence or Structural Similarity
more info
  
acts_upstream_of_or_within serotonin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within serotonin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
tryptophan 5-hydroxylase
Names
tryptophan 5-monooxygenase
tryptophan hydroxylase 1 S homeolog
NP_001080923.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001087454.1 → NP_001080923.1  tryptophan 5-hydroxylase

    See identical proteins and their annotated locations for NP_001080923.1

    Status: PROVISIONAL

    Source sequence(s)
    L20679
    UniProtKB/Swiss-Prot
    Q92142
    UniProtKB/TrEMBL
    A0A974HMY2
    Related
    ENSXLAP00005056086.1, ENSXLAT00005057315.1
    Conserved Domains (3) summary
    TIGR01270
    Location:53 → 476
    Trp_5_monoox; tryptophan 5-monooxygenase, tetrameric
    cd04929
    Location:55 → 128
    ACT_TPH; ACT domain of the nonheme iron-dependent aromatic amino acid hydroxylase, tryptophan hydroxylases (TPH), both peripheral (TPH1) and neuronal (TPH2) enzymes
    pfam00351
    Location:143 → 473
    Biopterin_H; Biopterin-dependent aromatic amino acid hydroxylase

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    491782..500495 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q92142.1 GenPept UniProtKB/Swiss-Prot:Q92142

Gene LinkOut

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