lin28a.S lin-28 homolog A S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: lin28a.S
Official Full Name: lin-28 homolog A S homeolog
Primary source: Xenbase:XB-GENE-866059
Locus tag: XELAEV_18015060mg
See related: EnsemblRapid:ENSXLAG00005008219 AllianceGenome:Xenbase:XB-GENE-866059
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: csdd1; lin28; lin-28; lin28a; zcchc1
Summary: Predicted to enable mRNA binding activity. Predicted to act upstream of or within positive regulation of cytoplasmic translation; pre-miRNA processing; and stem cell population maintenance. Predicted to be located in P-body; cytoplasmic stress granule; and nucleus. Is expressed in nervous system. Orthologous to human LIN28A (lin-28 homolog A). [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 2S

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	2S	NC_054374.1 (67146875..67166142)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	2S	NC_030727.1 (62938834..62958152)

Chromosome 2S - NC_054374.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the role of Lin28 in controlling developmental transitions is evolutionary conserved and establishes a functional interaction between Lin28 and thyroid hormone function.
Title: The heterochronic gene Lin28 regulates amphibian metamorphosis through disturbance of thyroid hormone function.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables mRNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of cytoplasmic translation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within pre-miRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within pre-miRNA processing	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within stem cell population maintenance	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in P-body	IEA Inferred from Electronic Annotation more info
located_in P-body	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytoplasmic stress granule	IEA Inferred from Electronic Annotation more info
located_in cytoplasmic stress granule	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in rough endoplasmic reticulum	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: protein lin-28 homolog A

Names: RNA-binding protein LIN-28A; lin-28A

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001087449.1 → NP_001080918.1 protein lin-28 homolog A

See identical proteins and their annotated locations for NP_001080918.1

Status: PROVISIONAL

Source sequence(s)

AF521098

UniProtKB/Swiss-Prot

Q8JHC4

UniProtKB/TrEMBL

A0A974DH95, B7ZPW6

Related

ENSXLAP00005023639.1, ENSXLAT00005024344.1

Conserved Domains (1) summary

cd04458
Location:36 → 105

CSP_CDS; Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box protein. ...