SPARC secreted protein acidic and cysteine rich [Gallus gallus (chicken)] - Gene

Summary

Symbol: SPARCprovided by CGNC
Full Name: secreted protein acidic and cysteine richprovided by CGNC
Primary source: CGNC:3072
See related: Ensembl:ENSGALG00010014390
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	13	NC_052544.1 (12522360..12530589)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	13	NC_052585.1 (12536122..12544352)

Chromosome 13 - NC_052544.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

This result indicates that the downregulation of RUNX2 and SPARC can contribute to an increased incidence of Bacterial chondronecrosis with osteomyelitis (BCO) in broilers.
Title: The involvement of RUNX2 and SPARC genes in the bacterial chondronecrosis with osteomyelitis in broilers.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables calcium ion binding	IEA Inferred from Electronic Annotation more info	PubMed
enables collagen binding	IEA Inferred from Electronic Annotation more info	PubMed
enables extracellular matrix binding	IEA Inferred from Electronic Annotation more info	PubMed
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in anatomical structure development	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular space	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: SPARC

Names: BM-40; ON; basement-membrane protein 40; osteonectin; secreted protein acidic and rich in cysteine; secreted protein, acidic, cysteine-rich (osteonectin)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_204410.2 → NP_989741.2 SPARC precursor

Status: PROVISIONAL

Source sequence(s)

JAENSK010000256

UniProtKB/Swiss-Prot

P36377

UniProtKB/TrEMBL

A0A8V0YVS5

Related

ENSGALP00010020361.1, ENSGALT00010034707.1

Conserved Domains (2) summary

cd01328
Location:66 → 147

FSL_SPARC; Follistatin-like SPARC (secreted protein, acidic, and rich in cysteines) domain; SPARC/BM-40/osteonectin is a multifunctional glycoprotein which modulates cellular interaction with the extracellular matrix by its binding to structural matrix proteins ...

cd16235
Location:150 → 289

EFh_SPARC_SPARC; EF-hand, extracellular calcium-binding (EC) motif, found in secreted protein acidic and rich in cysteine (SPARC)