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Txl Thioredoxin-like [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38646, updated on 22-Aug-2024

Summary

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Official Symbol
Txlprovided by FlyBase
Official Full Name
Thioredoxin-likeprovided by FlyBase
Primary source
FLYBASE:FBgn0035631
Locus tag
Dmel_CG5495
See related
AllianceGenome:FB:FBgn0035631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
5495; anon-WO0118547.248; CG5495; Dmel\CG5495; txl
Summary
Predicted to enable disulfide oxidoreductase activity. Is expressed in adult head. Orthologous to human TXNL1 (thioredoxin like 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
64E6-64E7; 3-15 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (5765846..5767084)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (5758946..5760184)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene small non-coding RNA:CR43603 Neighboring gene antisense RNA:CR45831 Neighboring gene Bifunctional Phosphopantetheine adenylyltransferase - Dephospho-CoA kinase Neighboring gene scrawny

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases. Maiorino M, et al. J Mol Biol, 2007 Jan 26. PMID 17098255
  2. Genomic structure and chromosomal localization of human thioredoxin-like protein gene (txl). Miranda-Vizuete A, et al. DNA Seq, 2000. PMID 10826702
  3. Genomic differentiation between temperate and tropical Australian populations of Drosophila melanogaster. Kolaczkowski B, et al. Genetics, 2011 Jan. PMID 21059887, Free PMC Article
  4. Ubiquitin-Binding Protein CG5445 Suppresses Aggregation and Cytotoxicity of Amyotrophic Lateral Sclerosis-Linked TDP-43 in Drosophila. Uechi H, et al. Mol Cell Biol, 2018 Feb 1. PMID 29109084, Free PMC Article
  5. Thioredoxin-2 affects lifespan and oxidative stress in Drosophila. Svensson MJ, et al. Hereditas, 2007 Mar. PMID 17567437

See all (43) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. e catalytic mechanism of DmGPx, unlike that of selenocysteine (Sec)GPxs, involves formation of an internal disulfide that is pivotal to the interaction with Trx
    Title: The thioredoxin specificity of Drosophila GPx: a paradigm for a peroxiredoxin-like mechanism of many glutathione peroxidases.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables protein-disulfide reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-disulfide reductase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Thioredoxin-like
Names
CG5495-PA
Txl-PA
thioredoxin

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    5765846..5767084
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_079214.4 → NP_523938.2  Thioredoxin-like [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_523938.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q7KMR7, Q9VRP3
    Related
    FBpp0076804
    Conserved Domains (2) summary
    cd02947
    Location:10 → 103
    TRX_family; TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox ...
    pfam06201
    Location:125 → 266
    PITH; PITH domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7KMR7 Q7KMR7
Q9VRP3 Q9VRP3

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