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Fit1 Fermitin 1 [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38488, updated on 2-Nov-2024

Summary

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Official Symbol
Fit1provided by FlyBase
Official Full Name
Fermitin 1provided by FlyBase
Primary source
FLYBASE:FBgn0035498
Locus tag
Dmel_CG14991
See related
AllianceGenome:FB:FBgn0035498
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
anon-WO0118547.421; CG14991; Dmel\CG14991; fit 1; Fit 1; fit1
Summary
Predicted to enable integrin binding activity. Involved in cardiac muscle tissue development and defense response to Gram-negative bacterium. Predicted to be located in cytoplasm. Predicted to be active in cell-substrate junction. Is expressed in adult head; adult heart; and organism. Human ortholog(s) of this gene implicated in Kindler syndrome; leukocyte adhesion deficiency 1; leukocyte adhesion deficiency 3; telangiectasis; and vesiculobullous skin disease. Orthologous to several human genes including FERMT1 (FERM domain containing kindlin 1) and FERMT2 (FERM domain containing kindlin 2). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
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Genomic context

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See Fit1 in Genome Data Viewer
Location:
64A6-64A6; 3-10 cM
Exon count:
1
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (4103564..4107116)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (4103564..4107116)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene Glutamic acid decarboxylase 1 Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR45670 Neighboring gene Activated Cdc42 kinase

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FERMT2 links cortical actin structures, plasma membrane tension and focal adhesion function to stabilize podocyte morphology. Yasuda-Yamahara M, et al. Matrix Biol, 2018 Aug. PMID 29337051
  2. Fermitins, the orthologs of mammalian Kindlins, regulate the development of a functional cardiac syncytium in Drosophila melanogaster. Catterson JH, et al. PLoS One, 2013. PMID 23690969, Free PMC Article
  3. Drosophila integrin adhesion complexes are essential for hemocyte migration in vivo. Moreira CG, et al. Biol Open, 2013 Aug 15. PMID 23951405, Free PMC Article
  4. Drosophila vinculin is more harmful when hyperactive than absent, and can circumvent integrin to form adhesion complexes. Maartens AP, et al. J Cell Sci, 2016 Dec 1. PMID 27737911, Free PMC Article
  5. Leading edge-secreted Dpp cooperates with ACK-dependent signaling from the amnioserosa to regulate myosin levels during dorsal closure. Zahedi B, et al. Dev Dyn, 2008 Oct. PMID 18816840

See all (51) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables cell adhesion molecule binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables integrin binding IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in cardiac muscle tissue development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in cell-matrix adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell-matrix adhesion ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in integrin-mediated signaling pathway IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cell-substrate junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
fermitin 1
Names
CG14991-PA
CG14991-PB
Fermitin1
Fit1-PA
Fit1-PB

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    4103564..4107116
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_139601.4 → NP_647858.2  fermitin 1, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_647858.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1G3, Q95SD2, Q9VZI3
    Related
    FBpp0073066
    Conserved Domains (5) summary
    cd01237
    Location:401 → 529
    PH_fermitin; Fermitin family pleckstrin homology (PH) domain
    cd13205
    Location:596 → 686
    FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
    pfam00169
    Location:401 → 508
    PH; PH domain
    pfam00373
    Location:538 → 602
    FERM_M; FERM central domain
    cl09511
    Location:305 → 348
    FERM_B-lobe; FERM domain B-lobe

  2. NM_168060.3 → NP_728936.1  fermitin 1, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_728936.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A4V1G3, Q95SD2, Q9VZI3
    Related
    FBpp0073065
    Conserved Domains (5) summary
    cd01237
    Location:401 → 529
    PH_fermitin; Fermitin family pleckstrin homology (PH) domain
    cd13205
    Location:596 → 686
    FERM_C_fermitin; FERM domain C-lobe of the Fermitin family
    pfam00169
    Location:401 → 508
    PH; PH domain
    pfam00373
    Location:538 → 602
    FERM_M; FERM central domain
    cl09511
    Location:305 → 348
    FERM_B-lobe; FERM domain B-lobe
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9VZI3.1 Q9VZI3

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