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Sac1 Sac1 phosphatase [ Drosophila melanogaster (fruit fly) ]

Gene ID: 38137, updated on 11-Sep-2024

Summary

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Official Symbol
Sac1provided by FlyBase
Official Full Name
Sac1 phosphataseprovided by FlyBase
Primary source
FLYBASE:FBgn0283500
Locus tag
Dmel_CG9128
See related
AllianceGenome:FB:FBgn0283500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
CG9128; Dmel\CG9128; dsac1; impatent; l(3)2107; sac1
Summary
Enables phosphatidylinositol-4-phosphate phosphatase activity. Involved in several processes, including dorsal closure, amnioserosa morphology change; negative regulation of signal transduction; and nervous system development. Located in axon; neuronal cell body; and sensory dendrite. Is expressed in several structures, including adult heart; embryonic/larval midgut; extended germ band embryo; larval longitudinal connective; and presumptive embryonic/larval system. Orthologous to human SACM1L (SAC1 like phosphatidylinositide phosphatase). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

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Location:
61F4-61F4; 3-0 cM
Exon count:
3
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3L NT_037436.4 (1247817..1250451)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3L NT_037436.3 (1247817..1250451)

Chromosome 3L - NT_037436.4Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene Partner of Sld Five 1 Neighboring gene Booster for Crq Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neither insufficiency nor overexpression of sac1 affects the accumulation of Aβ42 in Drosophila expressing Ab42. Han M, et al. Eur Rev Med Pharmacol Sci, 2015. PMID 26004612
  2. Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1. Griffiths NW, et al. Mol Biol Cell, 2020 May 15. PMID 32186963, Free PMC Article
  3. The phosphoinositide phosphatase Sac1 is required for midline axon guidance. Lee S, et al. Mol Cells, 2011 Nov. PMID 22042447, Free PMC Article
  4. The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila. Wei HC, et al. Curr Biol, 2003 Oct 28. PMID 14588244
  5. Synaptojanin regulates Hedgehog signalling by modulating phosphatidylinositol 4-phosphate levels. Ahaley SS. J Biosci, 2018 Dec. PMID 30541947

See all (49) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1.
    Title: Cellular homeostasis in the Drosophila retina requires the lipid phosphatase Sac1.
  2. The data reveal a novel requirement for Sac1 in promoting microtubule stability and suggest that Rst trafficking occurs in a microtubule- and exocyst-dependent manner.
    Title: The phosphoinositide phosphatase Sac1 regulates cell shape and microtubule stability in the developing Drosophila eye.
  3. Here, we present evidence that Sac1 regulates axon guidance in the embryonic CNS of Drosophila
    Title: The phosphoinositide phosphatase Sac1 is required for midline axon guidance.
  4. the first report of a role for Sac1 in the development of a multicellular organism
    Title: The Sac1 lipid phosphatase regulates cell shape change and the JNK cascade during dorsal closure in Drosophila.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables phosphatidylinositol phosphate phosphatase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phosphatidylinositol-4-phosphate phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol-4-phosphate phosphatase activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in axo-dendritic transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in axon midline choice point recognition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cytoplasmic microtubule organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in dorsal closure, amnioserosa morphology change IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lumen formation, open tracheal system HMP PubMed 
involved_in negative regulation of JNK cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in negative regulation of JNK cascade IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of smoothened signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol dephosphorylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol dephosphorylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in synapse maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in axon IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endomembrane system HDA PubMed 
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in neuronal cell body IDA
Inferred from Direct Assay
more info
 PubMed 
located_in sensory dendrite IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Sac1 phosphatase
Names
CG9128-PA
CG9128-PB
Sac1-PA
Sac1-PB
impatent
suppressor of actin-1
NP_001189016.1
NP_612087.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_037436.4 Reference assembly

    Range
    1247817..1250451
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001202087.1 → NP_001189016.1  Sac1 phosphatase, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001189016.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W0I6
    UniProtKB/TrEMBL
    M9MRM4
    Conserved Domains (2) summary
    COG5329
    Location:3 → 566
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam02383
    Location:62 → 344
    Syja_N; SacI homology domain

  2. NM_138243.4 → NP_612087.1  Sac1 phosphatase, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_612087.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9W0I6
    UniProtKB/TrEMBL
    M9MRM4
    Related
    FBpp0072546
    Conserved Domains (2) summary
    COG5329
    Location:3 → 566
    COG5329; Phosphoinositide polyphosphatase (Sac family) [Signal transduction mechanisms]
    pfam02383
    Location:62 → 344
    Syja_N; SacI homology domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
M9MRM4 M9MRM4
Q9W0I6.1 Q9W0I6

Gene LinkOut

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