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htr3a.L 5-hydroxytryptamine (serotonin) receptor 3A, ionotropic L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 379233, updated on 4-Nov-2024

Summary

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Official Symbol
htr3a.L
Official Full Name
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic L homeolog
Primary source
Xenbase:XB-GENE-6256362
Locus tag
XELAEV_18022549mg
See related
EnsemblRapid:ENSXLAG00005019245 AllianceGenome:Xenbase:XB-GENE-6256362
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
htr3a
Summary
Predicted to enable acetylcholine-gated monoatomic cation-selective channel activity and transmembrane signaling receptor activity. Predicted to act upstream of or within several processes, including chemical synaptic transmission; monoatomic ion transmembrane transport; and regulation of membrane potential. Predicted to be located in membrane; neuron projection; and synapse. Is expressed in dermal system. Human ortholog(s) of this gene implicated in alcohol dependence; cocaine dependence; heroin dependence; irritable bowel syndrome; and nicotine dependence. Orthologous to human HTR3A (5-hydroxytryptamine receptor 3A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See htr3a.L in Genome Data Viewer
Location:
chromosome: 4L
Exon count:
9
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 4L NC_054377.1 (44638862..44653770, complement)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 4L NC_030730.1 (42150497..42165455, complement)

Chromosome 4L - NC_054377.1Genomic Context describing neighboring genes Neighboring gene 5-hydroxytryptamine receptor 3A Neighboring gene 5-hydroxytryptamine receptor 3A Neighboring gene 5-hydroxytryptamine receptor 3A-like Neighboring gene carbohydrate sulfotransferase 6 like L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC52789

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables acetylcholine-gated monoatomic cation-selective channel activity IEA
Inferred from Electronic Annotation
more info
  
enables extracellular ligand-gated monoatomic ion channel activity IEA
Inferred from Electronic Annotation
more info
  
enables transmembrane signaling receptor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within chemical synaptic transmission IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within nervous system process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of membrane potential IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within signal transduction IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in neuron projection IEA
Inferred from Electronic Annotation
more info
  
located_in synapse IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
5-hydroxytryptamine (serotonin) receptor 3A, ionotropic L homeolog

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001086077.1 → NP_001079546.1  5-hydroxytryptamine (serotonin) receptor 3A, ionotropic L homeolog precursor

    See identical proteins and their annotated locations for NP_001079546.1

    Status: PROVISIONAL

    Source sequence(s)
    BC044101
    UniProtKB/TrEMBL
    A0A974D3H4, Q7ZTN5
    Related
    ENSXLAP00005056701.1, ENSXLAT00005057979.1
    Conserved Domains (2) summary
    pfam02931
    Location:43 → 236
    Neur_chan_LBD; Neurotransmitter-gated ion-channel ligand binding domain
    pfam02932
    Location:243 → 436
    Neur_chan_memb; Neurotransmitter-gated ion-channel transmembrane region

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054377.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    44638862..44653770 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

Gene LinkOut

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