rrm2b.S ribonucleotide reductase M2 B (TP53 inducible) S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: rrm2b.S
Official Full Name: ribonucleotide reductase M2 B (TP53 inducible) S homeolog
Primary source: Xenbase:XB-GENE-6251831
Locus tag: XELAEV_18030079mg
See related: EnsemblRapid:ENSXLAG00005018670 AllianceGenome:Xenbase:XB-GENE-6251831
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: p53r2; rrm2b
Summary: Predicted to enable metal ion binding activity and ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor. Predicted to act upstream of or within deoxyribonucleotide biosynthetic process. Predicted to be located in cytosol. Human ortholog(s) of this gene implicated in autosomal dominant progressive external ophthalmoplegia with mitochondrial DNA deletions 5; mitochondrial DNA depletion syndrome 8a; and mitochondrial DNA depletion syndrome 8b. Orthologous to human RRM2B (ribonucleotide reductase regulatory TP53 inducible subunit M2B). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 5S

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	5S	NC_054380.1 (125738858..125745657)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	5S	NC_030733.1 (119047251..119054050)

Chromosome 5S - NC_054380.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within deoxyribonucleotide biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nucleobase-containing small molecule metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: ribonucleotide reductase M2 B (TP53 inducible) S homeolog

NP_001079369.1

EC 1.17.4.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.