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CG11406 uncharacterized protein [ Drosophila melanogaster (fruit fly) ]

Gene ID: 37877, updated on 2-Nov-2024

Summary

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Official Symbol
CG11406provided by FlyBase
Official Full Name
uncharacterized proteinprovided by FlyBase
Primary source
FLYBASE:FBgn0034990
Locus tag
Dmel_CG11406
See related
AllianceGenome:FB:FBgn0034990
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Drosophila melanogaster
Lineage
Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
Also known as
Dmel\CG11406
Summary
Predicted to enable triacylglycerol lipase activity. Human ortholog(s) of this gene implicated in autosomal recessive congenital ichthyosis 8. Orthologous to human LIPK (lipase family member K); LIPM (lipase family member M); and LIPN (lipase family member N). [provided by Alliance of Genome Resources, Nov 2024]
Orthologs
all
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Genomic context

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See CG11406 in Genome Data Viewer
Location:
60C2-60C2; 2-106 cM
Exon count:
5
Annotation release Status Assembly Chr Location
Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 2R NT_033778.4 (24202091..24208203, complement)
Release 5.57 previous assembly Release 5 (GCF_000001215.2) 2R NT_033778.3 (20089614..20095726, complement)

Chromosome 2R - NT_033778.4Genomic Context describing neighboring genes Neighboring gene over compensating males Neighboring gene cytosolic 5'-nucleotidase IIIB Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene long non-coding RNA:CR44827

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Paucity of chimeric gene-transposable element transcripts in the Drosophila melanogaster genome. Lipatov M, et al. BMC Biol, 2005 Nov 12. PMID 16283942, Free PMC Article
  2. A Genetic Screen Using the Drosophila melanogaster TRiP RNAi Collection To Identify Metabolic Enzymes Required for Eye Development. Pletcher RC, et al. G3 (Bethesda), 2019 Jul 9. PMID 31036678, Free PMC Article
  3. A Superfamily-wide Activity Atlas of Serine Hydrolases in Drosophila melanogaster. Kumar K, et al. Biochemistry, 2021 Apr 27. PMID 33827210, Free PMC Article
  4. Genome-wide phenotypic RNAi screen in the Drosophila wing: phenotypic description of functional classes. López-Varea A, et al. G3 (Bethesda), 2021 Dec 8. PMID 34599810, Free PMC Article
  5. CRISPR-based modular assembly of a UAS-cDNA/ORF plasmid library for more than 5500 Drosophila genes conserved in humans. Wei P, et al. Genome Res, 2020 Jan. PMID 31722958, Free PMC Article

See all (20) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by FlyBase

Function Evidence Code Pubs
enables hydrolase activity, acting on ester bonds IEA
Inferred from Electronic Annotation
more info
  
enables triacylglycerol lipase activity ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
uncharacterized protein
Names
CG11406-PA
CG11406-PB
CG11406-PC
CG11406-PD
NP_001014548.1
NP_001163290.1
NP_001286832.1
NP_611897.2

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NT_033778.4 Reference assembly

    Range
    24202091..24208203 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001014548.2 → NP_001014548.1  uncharacterized protein Dmel_CG11406, isoform B [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001014548.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q59E63
    Conserved Domains (3) summary
    pfam00561
    Location:67 → 371
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam04083
    Location:28 → 85
    Abhydro_lipase; Partial alpha/beta-hydrolase lipase region
    pfam12695
    Location:67 → 203
    Abhydrolase_5; Alpha/beta hydrolase family

  2. NM_138053.4 → NP_611897.2  uncharacterized protein Dmel_CG11406, isoform A [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_611897.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9W195
    Conserved Domains (3) summary
    pfam00561
    Location:2 → 301
    Abhydrolase_1; alpha/beta hydrolase fold
    pfam12695
    Location:245 → 295
    Abhydrolase_5; Alpha/beta hydrolase family
    cl21494
    Location:2 → 110
    Abhydrolase; alpha/beta hydrolases

  3. NM_001169819.2 → NP_001163290.1  uncharacterized protein Dmel_CG11406, isoform C [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001163290.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JGW0, Q3KN49
    Conserved Domains (1) summary
    cl21494
    Location:2 → 110
    Abhydrolase; alpha/beta hydrolases

  4. NM_001299903.1 → NP_001286832.1  uncharacterized protein Dmel_CG11406, isoform D [Drosophila melanogaster]

    See identical proteins and their annotated locations for NP_001286832.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1JGW0, Q3KN49
    Conserved Domains (1) summary
    cl21494
    Location:2 → 110
    Abhydrolase; alpha/beta hydrolases
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
E1JGW0 E1JGW0
Q59E63 Q59E63
Q9W195 Q9W195

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