sp5.S Sp5 transcription factor S homeolog [Xenopus laevis (African clawed frog)] - Gene

Summary

Official Symbol: sp5.S
Official Full Name: Sp5 transcription factor S homeolog
Primary source: Xenbase:XB-GENE-1217613
Locus tag: XELAEV_18047161mg
See related: EnsemblRapid:ENSXLAG00005025056 AllianceGenome:Xenbase:XB-GENE-1217613
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Xenopus laevis
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as: sp5; spr1; xsp5; XSPR-1; spr1-A
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to act upstream of or within regulation of transcription by RNA polymerase II. Is expressed in ectoderm; mesoderm; musculoskeletal system; nervous system; and vestibuloauditory system. Orthologous to human SP5 (Sp5 transcription factor). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

Location:: chromosome: 9_10S

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
101	current	Xenopus_laevis_v10.1 (GCF_017654675.1)	9_10S	NC_054388.1 (66202552..66207578)
100	previous assembly	Xenopus_laevis_v2 (GCF_001663975.1)	9_10S	NC_030741.1 (59540192..59545218)

Chromosome 9_10S - NC_054388.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Results show that fibroblast growth factor 16 (FGF16) can activate the MAPK pathway and expression of Sp5 transcription factor S (sp5) and Sp5 transcription factor L (sp5l).
Title: Xenopus laevis FGF16 activates the expression of genes coding for the transcription factors Sp5 and Sp5l.
Sp5 functions as a critical early factor in the genetic cascade to regulate neural crest induction downstream of Wnt and FGF pathways.
Title: Role of Sp5 as an essential early regulator of neural crest specification in xenopus.

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General gene information

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Gene Ontology Provided by Xenbase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Sp5 transcription factor S homeolog; sp5 transcription factor S homeolog

Names: Sp1-like zinc-finger protein XSPR-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001085859.1 → NP_001079328.1 Sp5 transcription factor S homeolog

See identical proteins and their annotated locations for NP_001079328.1

Status: PROVISIONAL

Source sequence(s)

AY062264

UniProtKB/TrEMBL

A0A974BUA2, Q8UUU3

Related

ENSXLAP00005074331.1, ENSXLAT00005075912.1

Conserved Domains (4) summary

COG5048
Location:158 → 360

COG5048; FOG: Zn-finger [General function prediction only]

sd00017
Location:276 → 295

ZF_C2H2; C2H2 Zn finger [structural motif]

pfam00096
Location:331 → 353

zf-C2H2; Zinc finger, C2H2 type

pfam13465
Location:317 → 340

zf-H2C2_2; Zinc-finger double domain