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erg.L v-ets avian erythroblastosis virus E26 oncogene homolog L homeolog [ Xenopus laevis (African clawed frog) ]

Gene ID: 378618, updated on 4-Nov-2024

Summary

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Official Symbol
erg.L
Official Full Name
v-ets avian erythroblastosis virus E26 oncogene homolog L homeolog
Primary source
Xenbase:XB-GENE-6085058
Locus tag
XELAEV_18011439mg
See related
EnsemblRapid:ENSXLAG00005032163 AllianceGenome:Xenbase:XB-GENE-6085058
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Xenopus laevis
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia; Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus
Also known as
erg; p55; erg-3; erg-a; erg-b; erg_A
Summary
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Predicted to act upstream of or within cell differentiation and regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Is expressed in cardiovascular system; nervous system; and pharyngeal arch. Human ortholog(s) of this gene implicated in hereditary lymphedema and myeloid leukemia. Orthologous to human ERG (ETS transcription factor ERG). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
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Genomic context

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See erg.L in Genome Data Viewer
Location:
chromosome: 2L
Exon count:
10
Annotation release Status Assembly Chr Location
101 current Xenopus_laevis_v10.1 (GCF_017654675.1) 2L NC_054373.1 (11570132..11604866)
100 previous assembly Xenopus_laevis_v2 (GCF_001663975.1) 2L NC_030726.1 (11341040..11375811)

Chromosome 2L - NC_054373.1Genomic Context describing neighboring genes Neighboring gene small Cajal body-specific RNA 8 Neighboring gene proteasome (prosome, macropain) assembly chaperone 1 L homeolog Neighboring gene v-ets avian erythroblastosis virus E26 oncogene homolog 2 L homeolog Neighboring gene potassium inwardly rectifying channel subfamily J member 15 L homeolog Neighboring gene potassium inwardly rectifying channel subfamily J member 6 L homeolog

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Xl erg: expression pattern and overexpression during development plead for a role in endothelial cell differentiation. Baltzinger M, et al. Dev Dyn, 1999 Dec. PMID 10633861
  2. Identification of interaction partners for two closely-related members of the ETS protein family, FLI and ERG. Deramaudt TB, et al. Gene, 2001 Aug 22. PMID 11675009
  3. Genetic and genomic tools for Xenopus research: The NIH Xenopus initiative. Klein SL, et al. Dev Dyn, 2002 Dec. PMID 12454917
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by Xenbase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
  
enables sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within cell differentiation IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
v-ets avian erythroblastosis virus E26 oncogene homolog L homeolog
Names
v-ets erythroblastosis virus E26 oncogene homolog
v-ets erythroblastosis virus E26 oncogene like
vascular ETS factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001085840.2 → NP_001079309.1  v-ets avian erythroblastosis virus E26 oncogene homolog L homeolog

    See identical proteins and their annotated locations for NP_001079309.1

    Status: PROVISIONAL

    Source sequence(s)
    AJ224125
    UniProtKB/TrEMBL
    A0A974DG45, Q9W700
    Related
    ENSXLAP00005096327.1, ENSXLAT00005098102.1
    Conserved Domains (3) summary
    pfam04817
    Location:241 → 295
    Umbravirus_LDM; Umbravirus long distance movement (LDM) family
    cd08540
    Location:136 → 210
    SAM_PNT-ERG; Sterile alpha motif (SAM)/Pointed domain of ERG transcription factor
    smart00413
    Location:316 → 399
    ETS; erythroblast transformation specific domain

RefSeqs of Annotated Genomes: Xenopus laevis Annotation Release 101 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference Xenopus_laevis_v10.1 Primary Assembly

Genomic

  1. NC_054373.1 Reference Xenopus_laevis_v10.1 Primary Assembly

    Range
    11570132..11604866
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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Research Materials